One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

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• dc.contributor.author Díez-Ricote, Laura
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author Malcampo, Mireia
• dc.contributor.author Gasulla, Griselda
• dc.contributor.author Herraiz, Xavier
• dc.contributor.author Daimiel, Lidia
• dc.date.accessioned 2023-01-13T07:33:16Z
• dc.date.available 2023-01-13T07:33:16Z
• dc.date.issued 2022
• dc.description.abstract Background: choline and betaine intakes have been related to cardiovascular health. Objectives: we aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. Methods: we used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. Results: the greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (-3.39 and -2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (-0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (-2.93 and -2.78 kg, respectively), BMI (-1.05 and -0.99, respectively), waist circumference (-3.37 and -3.26 cm, respectively), total cholesterol (-4.74 and -4.52 mg/dL, respectively), and LDL cholesterol (-4.30 and -4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (-5.42 and -5.74 mg/dL, respectively). Conclusions: increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation.This trial was registered at https://www.isrctn.com/ as ISRCTN89898870.
• dc.description.sponsorship Supported by Ministerio de Ciencia e Innovación through Proyectos de I+D+i “Retos Investigación” grant RTI2018-095569-B-I00 (to JMO) and “Programación Conjunta Internacional” grant PCI2018-093009 (to JMO). The PREDIMED-Plus (Prevención con Dieta Mediterránea-Plus) trial was supported by European Research Council Advanced Research grant 2014–2019, agreement #340918 (to MÁM-G); the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS) which is cofunded by the European Regional Development Fund (coordinated FIS projects led by JS-S and J Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, and PI20/01158), and the Especial Action Project “Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus” (to JS-S); and Recercaixa grant 2013ACUP00194 (to JS-S). Moreover, JS-S acknowledges the financial support by ICREA (Catalan Institution for Research and Advanced Studies) under the ICREA Academia program; the SEMERGEN grant (to JL); Government of Navarra Department of Health grant 61/2015 (to MÁM-G); Fundació La Marató de TV3 grant 201630.10; the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (to DC); Consejería de Salud de la Junta de Andalucía grants PI0458/2013, PS0358/2016, and PI0137/2018; Generalitat Valenciana grant PROMETEO/2017/017 (to DC); and Balearic Islands Government grant of support to research groups 35/2011 (FEDER funds) (to JAT). RS-C was supported by Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades Spanish State Research Agency Juan de la Cierva Program training grant FJC2018-038168-I.
• dc.format.mimetype application/pdf
• dc.identifier.citation Díez-Ricote L, San-Cristobal R, Concejo MJ, Martínez-González MÁ, Corella D, Salas-Salvadó J, et al. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial. Am J Clin Nutr. 2022 Dec 19; 116(6): 1565-79. DOI: 10.1093/ajcn/nqac255
• dc.identifier.doi http://dx.doi.org/10.1093/ajcn/nqac255
• dc.identifier.issn 0002-9165
• dc.identifier.uri http://hdl.handle.net/10230/55267
• dc.language.iso eng
• dc.publisher American Society for Nutrition
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-095569-B-I00
• dc.rights Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact moc.puo@snoissimrep.slanruoj
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Betaine
• dc.subject.keyword Cardiometabolic parameters
• dc.subject.keyword Cardiovascular disease risk
• dc.subject.keyword Choline
• dc.subject.keyword Renal variables
• dc.title One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion