Specific susceptibility to COVID-19 in adults with Down Syndrome

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  • dc.contributor.author Illouz, Tomer
  • dc.contributor.author Dierssen, Mara
  • dc.contributor.author De Toma, Ilario
  • dc.contributor.author Okun, Eitan
  • dc.date.accessioned 2022-06-07T09:06:08Z
  • dc.date.available 2022-06-07T09:06:08Z
  • dc.date.issued 2021
  • dc.description.abstract The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer's disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.
  • dc.description.sponsorship This research was supported by the Trisomy-21 Research Society (T21RS) and in part by the Intramural Research Program of the National Institute on Aging
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E et al. Specific susceptibility to COVID-19 in adults with Down Syndrome. Neuromolecular Med. 2021 Dec;23(4):561-571. DOI:10.1007/s12017-021-08651-5
  • dc.identifier.doi http://dx.doi.org/10.1007/s12017-021-08651-5
  • dc.identifier.issn 1535-1084
  • dc.identifier.uri http://hdl.handle.net/10230/53399
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.rights © Tomer Illouz et al. 2021, corrected publication 2021.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other COVID-19 (Malaltia)
  • dc.subject.other Down, Síndrome de
  • dc.title Specific susceptibility to COVID-19 in adults with Down Syndrome
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion