Developmental regulation of X-chromosome inactivation

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  • dc.contributor.author Payer, Bernhardca
  • dc.date.accessioned 2017-05-22T11:24:28Z
  • dc.date.issued 2016
  • dc.description.abstract With the emergence of sex-determination by sex chromosomes, which differ in composition and number between males and females, appeared the need to equalize X-chromosomal gene dosage between the sexes. Mammals have devised the strategy of X-chromosome inactivation (XCI), in which one of the two X-chromosomes is rendered transcriptionally silent in females. In the mouse, the best-studied model organism with respect to XCI, this inactivation process occurs in different forms, imprinted and random, interspersed by periods of X-chromosome reactivation (XCR), which is needed to switch between the different modes of XCI. In this review, I describe the recent advances with respect to the developmental control of XCI and XCR and in particular their link to differentiation and pluripotency. Furthermore, I review the mechanisms, which influence the timing and choice, with which one of the two X-chromosomes is chosen for inactivation during random XCI. This has an impact on how females are mosaics with regard to which X-chromosome is active in different cells, which has implications on the severity of diseases caused by X-linked mutations.
  • dc.description.sponsorship The work was supported by the Spanish Ministry of Economy and Competitiveness,'Centro de Excelencia Severo Ochoa 2013–2017', SEV-2012-0208 and for a Plan Estatal Grant to B.P. (BFU2014-55275-P)
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Payer B. Developmental regulation of X-chromosome inactivation. Semin Cell Dev Biol. 2016 Aug;56:88-99. DOI: 10.1016/j.semcdb.2016.04.014
  • dc.identifier.doi http://dx.doi.org/10.1016/j.semcdb.2016.04.014
  • dc.identifier.issn 1084-9521
  • dc.identifier.uri http://hdl.handle.net/10230/32141
  • dc.language.iso eng
  • dc.publisher Elsevierca
  • dc.relation.ispartof Seminars in Cell and Developmental Biology. 2016 Aug;56:88-99
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55275-P
  • dc.rights © Elsevier http://dx.doi.org/10.1016/j.semcdb.2016.04.014
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Cromosoma X
  • dc.subject.other Epigenètica
  • dc.subject.other RNA
  • dc.title Developmental regulation of X-chromosome inactivationca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)