Interaction between airborne copper exposure and ATP7B polymorphisms on inattentiveness in scholar children

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• dc.contributor.author Alemany, Silvia
• dc.contributor.author Vilor Tejedor, Natàlia, 1988-
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author Álvarez Pedrerol, Mar, 1981-
• dc.contributor.author Rivas, Ioar
• dc.contributor.author Forns i Guzman, Joan, 1981-
• dc.contributor.author Querol, Xavier
• dc.contributor.author Pujol Martí, Jesús, 1981-
• dc.contributor.author Sunyer Deu, Jordi
• dc.date.accessioned 2023-11-21T06:39:51Z
• dc.date.available 2023-11-21T06:39:51Z
• dc.date.issued 2017
• dc.description.abstract Recent research indicates that airborne copper exposure in scholar children negatively affects brain functioning. These effects are likely to be influenced by the efficiency of copper metabolism, which is partly regulated by the ATPase copper transporting beta (ATP7B) gene. We investigated whether indoor and outdoor airborne copper exposure is differentially associated with child inattentiveness depending on genetic variation within the ATP7B gene in 1645 scholar children from the BREATHE project. Outdoor (courtyard) and indoor (classroom) air pollution levels were measured during class hours in each school. Inattentiveness was assessed through a follow-up with four measurements via the Attentional Network Test (4475 observations). Linear mixed models considering repeated measures were conducted to assess genetic and exposure main and interaction effects. Two interactions were detected indicating that ATP7B-rs1061472 (P for interaction 0.016) and ATP7B-rs1801243 (P for interaction 0.003) polymorphisms modified the association between indoor copper exposure and inattentiveness. Stratified analysis by genotypes revealed that both outdoor and indoor copper exposure increased inattentiveness in rs1061472-CC and rs1801243-CC carriers. These findings suggest that the genetic background promotes the association between airborne copper exposure at school with inattentiveness in children.
• dc.description.sponsorship The research leading to these results has received funding from the European Research Council under the ERC Grant Agreement number 268479- the BREATHE project. S. Alemany thanks the ‘Instituto de Salud Carlos III’ for her postdoctoral grant (CD14/00214). N. Vilor-Tejedor is funded by a pre-doctoral grant from the Agència de Gestió d’Ajuts Universitaris i de Recerca (2015 FI_B 00636) Generalitat de Catalunya.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alemany S, Vilor-Tejedor N, Bustamante M, Álvarez-Pedrerol M, Rivas I, Forns J, Querol X, Pujol J, Sunyer J. Interaction between airborne copper exposure and ATP7B polymorphisms on inattentiveness in scholar children. Int J Hyg Environ Health. 2017 Jan;220(1):51-6. DOI: 10.1016/j.ijheh.2016.10.010
• dc.identifier.doi http://dx.doi.org/10.1016/j.ijheh.2016.10.010
• dc.identifier.issn 1438-4639
• dc.identifier.uri http://hdl.handle.net/10230/58322
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Int J Hyg Environ Health. 2017 Jan;220(1):51-6
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.ijheh.2016.10.010
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.title Interaction between airborne copper exposure and ATP7B polymorphisms on inattentiveness in scholar children
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion