Anthropometric variables as mediators of the association of changes in diet and physical activity with inflammatory profile

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• dc.contributor.author Cárdenas Fuentes, Gabriela, 1985-
• dc.contributor.author Lassale, Camille
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Grau Magaña, Maria
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Corella, Dolores
• dc.contributor.author Serra Majem, Lluís
• dc.contributor.author Warnberg, Julia
• dc.contributor.author Konieczna, Jadwiga
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Pintó Sala, Xavier
• dc.contributor.author Martínez, José Alfredo
• dc.contributor.author Vázquez, Clotilde
• dc.contributor.author Vidal Alaball, Josep
• dc.contributor.author Tur, J. Antoni
• dc.contributor.author Díaz López, Andrés
• dc.contributor.author Lancova, Hana
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Schröder, Helmut, 1958-
• dc.date.accessioned 2021-10-01T05:53:15Z
• dc.date.issued 2021
• dc.description.abstract Background: Mechanisms underlying the associations of high levels of physical activity (PA) and adherence to the Mediterranean Diet (MedDiet) with a better inflammatory profile remain unclear. Our objective was to assess the mediating role of changes in body mass index (BMI) and waist circumference (WC), as markers of body fat in the association of changes in PA and adherence to the MedDiet, with changes in the inflammatory profile. Methods: This study included 489 adults, aged 55 to 75 years, from the PREDIMED-Plus multi-centre lifestyle intervention trial. An inflammatory score was calculated, based on 8 blood biomarkers: high-sensitivity C-reactive protein, interleukin 6, interleukin 8, interleukin 18, monocyte chemo-attractant protein-1, C-peptide, leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES). Biomarkers, levels of PA, score of MedDiet adherence, BMI and WC were measured at baseline and at one-year follow-up. Linear regression models were fitted according to the Baron and Kenny framework for mediation analysis. Results: Changes in BMI and WC mediated the association of both changes in PA and changes in the MedDiet adherence with the inflammatory score. BMI mediated 26% of the association of changes in total PA with the inflammatory profile, and 27% of the association of changes in the MedDiet, while WC mediated 13% and 12% of these associations, respectively. Conclusion: In older adults at high cardiovascular risk, increasing PA levels and adherence to a MedDiet during 1 year were associated with a lower inflammatory score, which was partly mediated by a reduction in body fat.
• dc.format.mimetype application/pdf
• dc.identifier.citation Cárdenas-Fuentes G, Lassale C, Martínez-González J MÁ, Grau M, Salas-Salvadó J, Corella D, Serra-Majem L, Warnberg J, Konieczna J, Estruch R, Pintó X, Martínez JA, Vázquez C, Vidal J, Tur JA, Díaz-López A, Lancova H, Fito M, Schröder H. Anthropometric variables as mediators of the association of changes in diet and physical activity with inflammatory profile. J Gerontol A Biol Sci Med Sci. 2021;76(11):2021-9. DOI: 10.1093/gerona/glab072
• dc.identifier.doi http://dx.doi.org/10.1093/gerona/glab072
• dc.identifier.issn 1079-5006
• dc.identifier.uri http://hdl.handle.net/10230/48544
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof J Gerontol A Biol Sci Med Sci. 2021;76(11):2021-9
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in The journals of gerontology. Series A, Biological sciences and medical sciences following peer review. The version of record Cárdenas-Fuentes G, Lassale C, Martínez-González J MÁ, Grau M, Salas-Salvadó J, Corella D, Serra-Majem L, Warnberg J, Konieczna J, Estruch R, Pintó X, Martínez JA, Vázquez C, Vidal J, Tur JA, Díaz-López A, Lancova H, Fito M, Schröder H. Anthropometric variables as mediators of the association of changes in diet and physical activity with inflammatory profile. J Gerontol A Biol Sci Med Sci. 2021;76(11):2021-9. DOI: 10.1093/gerona/glab072 is available online at: http://dx.doi.org/10.1093/gerona/glab072.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Body mass index
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Inflammation
• dc.subject.keyword Mediation analysis
• dc.subject.keyword Waist circumference
• dc.title Anthropometric variables as mediators of the association of changes in diet and physical activity with inflammatory profile
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion