Parametric modeling of mechanical effects on circadian oscillators

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• dc.contributor.author Kennedy, Keith Endres
• dc.contributor.author Abenza, Juan F.
• dc.contributor.author Rossetti, Leone
• dc.contributor.author Trepat, Xavier
• dc.contributor.author Villoslada, Pablo
• dc.contributor.author García Ojalvo, Jordi
• dc.date.accessioned 2024-01-25T08:03:29Z
• dc.date.available 2024-01-25T08:03:29Z
• dc.date.issued 2024
• dc.description.abstract Circadian rhythms are archetypal examples of nonlinear oscillations. While these oscillations are usually attributed to circuits of biochemical interactions among clock genes and proteins, recent experimental studies reveal that they are also affected by the cell's mechanical environment. Here, we extend a standard biochemical model of circadian rhythmicity to include mechanical effects in a parametric manner. Using experimental observations to constrain the model, we suggest specific ways in which the mechanical signal might affect the clock. Additionally, a bifurcation analysis of the system predicts that these mechanical signals need to be within an optimal range for circadian oscillations to occur.
• dc.description.sponsorship This work was supported by Project Nos. PID2021-127311NB-I00 and PGC2018-099645-B-I00, financed by the Spanish Ministry of Science and Innovation, the Spanish State Research Agency, and FEDER (MICIN/AEI/10.13039/501100011033/FEDER), by the Maria de Maeztu Programme for Units of Excellence in R&D (Project No. CEX2018-000792-M), and by the Generalitat de Catalunya (ICREA Academia programme). Additional funding was provided by the Generalitat de Catalunya (AGAUR 2021 SGR 01425 and 2021 SGR 00175, and the CERCA Programme), and the European Research Council (Adv-883739). IBEC is a recipient of a Severo Ochoa Award of Excellence from the Ministry for Science and Innovation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Kennedy KE, Abenza JF, Rossetti L, Trepat X, Villoslada P, Garcia-Ojalvo J. Parametric modeling of mechanical effects on circadian oscillators. Chaos. 2024 Jan 1;34(1):013135. DOI: 10.1063/5.0164829
• dc.identifier.doi http://dx.doi.org/10.1063/5.0164829
• dc.identifier.issn 1054-1500
• dc.identifier.uri http://hdl.handle.net/10230/58820
• dc.language.iso eng
• dc.publisher American Institute of Physics (AIP)
• dc.relation.ispartof Chaos. 2024 Jan 1;34(1):013135
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-127311NB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-099645-B-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000792-M
• dc.rights © American Institute of Physics. The following article appeared in Kennedy KE, Abenza JF, Rossetti L, Trepat X, Villoslada P, Garcia-Ojalvo J. Parametric modeling of mechanical effects on circadian oscillators. Chaos. 2024 Jan 1;34(1):013135 and may be found at https://doi.org/10.1063/5.0164829
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Nonlinear systems
• dc.subject.keyword Clocks
• dc.subject.keyword Biological systems and models
• dc.subject.keyword Cell biology
• dc.subject.keyword Goodwin oscillator
• dc.subject.keyword Gene network
• dc.subject.keyword Systems biology
• dc.subject.keyword Circadian rhythms
• dc.title Parametric modeling of mechanical effects on circadian oscillators
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion