Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study

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  • dc.contributor.author Campos Sánchez, Irene
  • dc.contributor.author Navarrete-Muñoz, Eva-María
  • dc.contributor.author Hurtado Pomares, Miriam
  • dc.contributor.author Júlvez Calvo, Jordi
  • dc.contributor.author Lertxundi, Nerea
  • dc.contributor.author Martens, Dries S.
  • dc.contributor.author Fernández Somoano, Ana
  • dc.contributor.author Riaño-Galán, Isolina
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Nawrot, Tim S.
  • dc.contributor.author Valera-Gran, Desirée
  • dc.date.accessioned 2024-06-20T07:04:21Z
  • dc.date.available 2024-06-20T07:04:21Z
  • dc.date.issued 2024
  • dc.description Data de publicació eelctrònica: 22-01-2024
  • dc.description.abstract Shortened telomere length (TL) has been associated with lower cognitive performance, different neurological diseases in adults, and certain neurodevelopmental disorders in children. However, the evidence about the association between TL and neuropsychological developmental outcomes in children from the general population is scarce. Therefore, this study aimed to explore the association between TL and neuropsychological function in children 4-5 years of age. We included 686 children from the INMA Project, a population-based birth cohort in Spain. Leucocyte TL was determined by quantitative PCR method, and neuropsychological outcomes were measured using the McCarthy Scales of Children's Abilities (MCSA). Multiple linear regression models were used to estimate associations adjusted for potential confounding variables. Main findings showed that a longer TL was associated with a higher mean working memory score (β = 4.55; 95% CI = 0.39, 8.71). In addition, longer TL was associated with a higher mean global quantitative score (β = 3.85; 95% CI = -0.19, 7.89), although the association was marginally significant. To our knowledge, this is the first study that shows a positive association between TL and better neuropsychological outcomes in children. Although further research is required to confirm these results, this study supports the hypothesis that TL is essential in protecting and maintaining a child's health, including cognitive functions such as working memory.
  • dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The present study has been funded by the Instituto de Salud Carlos III/Agencia Estatal de Investigación (PI18/00825) about the Project: “Diet and physical activity in Pregnancy and after birth and telomere length in Children and adolescents: TeloDiPA Project” and by the Department of Innovation, Universities, Science and Digital Society of Valencian Community for the Project “Telomere length and neuropsychological development between 4 and 8 years: TeloNeuro Project (GVA/2021/191)”. IC is the recipient of the fellowship “Formación de Profesorado Universitario (FPU)” from the Ministry of Education in Spain (FPU21/01323). DMS holds a postdoctoral grant from the Research Foundation Flanders (FWO 12X9620N, 12X9623N). In INMA-Asturias this study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), FIS-PI042018 incl. FEDER funds, FIS-PI09/02311 incl. FEDER funds, FIS-PI13/02429 incl. FEDER funds, FIS-PI18/00909 incl. FEDER funds, CIBERESP, Obra Social Cajastur/Fundación Liberbank and Universidad de Oviedo. In INMA-Gipuzkoa the study was funded by grants from Instituto de Salud Carlos III (FIS-PI09/00090 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2013111089), and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). Finally, INMA-Sabadell holds a research Miguel Servet-II contract (grants CPII19/00015 and CPII18/00018, respectively) awarded by the Spanish Instituto de Salud Carlos III (cofunded by the European Social Fund “Investing in your future”) to fund this study. We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Campos-Sánchez I, Navarrete-Muñoz EM, Hurtado-Pomares M, Júlvez J, Lertxundi N, Martens DS, et al. Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study. Eur Child Adolesc Psychiatry. 2024 Jan 22. DOI: 10.1007/s00787-023-02361-y
  • dc.identifier.doi http://dx.doi.org/10.1007/s00787-023-02361-y
  • dc.identifier.issn 1018-8827
  • dc.identifier.uri http://hdl.handle.net/10230/60528
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Eur Child Adolesc Psychiatry. 2024 Jan 22
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Children
  • dc.subject.keyword Neuropsychological function
  • dc.subject.keyword Telomere length
  • dc.subject.keyword Working memory
  • dc.title Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)