Nitrosative and oxidative stress, reduced antioxidant capacity, and fiber type switch in iron-deficient copd patients: analysis of muscle and systemic compartments
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Pérez-Peiró, Maria
- dc.contributor.author Alvarado Miranda, Mariela
- dc.contributor.author Martín-Ontiyuelo, Clara
- dc.contributor.author Rodríguez Chiaradía, Diego Agustín
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2023-06-20T10:29:58Z
- dc.date.available 2023-06-20T10:29:58Z
- dc.date.issued 2023
- dc.description.abstract We hypothesized that a rise in the levels of oxidative/nitrosative stress markers and a decline in antioxidants might take place in systemic and muscle compartments of chronic obstructive pulmonary disease (COPD) patients with non-anemic iron deficiency. In COPD patients with/without iron depletion (n = 20/group), markers of oxidative/nitrosative stress and antioxidants were determined in blood and vastus lateralis (biopsies, muscle fiber phenotype). Iron metabolism, exercise, and limb muscle strength were assessed in all patients. In iron-deficient COPD compared to non-iron deficient patients, oxidative (lipofuscin) and nitrosative stress levels were greater in muscle and blood compartments and proportions of fast-twitch fibers, whereas levels of mitochondrial superoxide dismutase (SOD) and Trolox equivalent antioxidant capacity (TEAC) decreased. In severe COPD, nitrosative stress and reduced antioxidant capacity were demonstrated in vastus lateralis and systemic compartments of iron-deficient patients. The slow- to fast-twitch muscle fiber switch towards a less resistant phenotype was significantly more prominent in muscles of these patients. Iron deficiency is associated with a specific pattern of nitrosative and oxidative stress and reduced antioxidant capacity in severe COPD irrespective of quadriceps muscle function. In clinical settings, parameters of iron metabolism and content should be routinely quantify given its implications in redox balance and exercise tolerance.
- dc.format.mimetype application/pdf
- dc.identifier.citation Pérez-Peiró M, Alvarado M, Martín-Ontiyuelo C, Rodríguez-Chiaradía DA, Barreiro E. Nitrosative and oxidative stress, reduced antioxidant capacity, and fiber type switch in iron-deficient copd patients: analysis of muscle and systemic compartments. Nutrients. 2023 Mar 2;15(6):1454. DOI: 10.3390/nu15061454
- dc.identifier.doi http://dx.doi.org/10.3390/nu15061454
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/57274
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2023 Mar 2;15(6):1454
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword COPD
- dc.subject.keyword Non-anemic iron deficiency
- dc.subject.keyword Nitrosative stress
- dc.subject.keyword Antioxidant systems
- dc.subject.keyword Lipofuscin inclusions
- dc.subject.keyword Muscle fiber type switch
- dc.subject.keyword Muscle and systemic compartments
- dc.title Nitrosative and oxidative stress, reduced antioxidant capacity, and fiber type switch in iron-deficient copd patients: analysis of muscle and systemic compartments
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion