Swallowed topical corticosteroids for eosinophilic esophagitis: Utilization and real-world efficacy from the EoE CONNECT registry

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Laserna-Mendieta, Emilio J.
• dc.contributor.author Navés, Juan Enrique
• dc.contributor.author EUREOS and EoE CONNECT research group
• dc.date.accessioned 2025-07-21T06:01:11Z
• dc.date.available 2025-07-21T06:01:11Z
• dc.date.issued 2024
• dc.description.abstract Background: Swallowed topical corticosteroids (tC) are common therapy for patients with eosinophilic esophagitis (EoE). Widely heterogeneous results have occurred due to their active ingredients, formulations and doses. Objective: To assess the effectiveness of topical corticosteroid therapy for EoE in real-world practice. Methods: Cross-sectional study analysis of the multicentre EoE CONNECT registry. Clinical remission was defined as a decrease of ≥50% in dysphagia symptom scores; histological remission was defined as a peak eosinophil count below 15 per high-power field. The effectiveness in achieving clinico-histological remission (CHR) was compared for the main tC formulations. Results: Overall, data on 1456 prescriptions of tC in monotherapy used in 866 individual patients were assessed. Of those, 904 prescriptions with data on formulation were employed for the induction of remission; 234 reduced a previously effective dose for maintenance. Fluticasone propionate formulations dominated the first-line treatment, while budesonide was more common in later therapies. A swallowed nasal drop suspension was the most common formulation of fluticasone propionate. Doses ≥0.8 mg/day provided a 65% CHR rate and were superior to lower doses. Oral viscous solution prepared by a pharmacist was the most common prescription of budesonide; 4 mg/day provided no benefit over 2 mg/day (CHR rated being 72% and 80%, respectively). A multivariate analysis revealed budesonide orodispersible tablets as the most effective therapy (OR 18.9, p < 0.001); use of higher doses (OR 4.3, p = 0.03) and lower symptom scores (OR 0.9, p = 0.01) were also determinants of effectiveness. Conclusion: Reduced symptom severity, use of high doses, and use of budesonide orodispersible tablets particularly were all independent predictors of tC effectiveness.
• dc.format.mimetype application/pdf
• dc.identifier.citation Laserna-Mendieta EJ, Navarro P, Casabona-Francés S, Savarino EV, Amorena E, Pérez-Martínez I, et al. Swallowed topical corticosteroids for eosinophilic esophagitis: Utilization and real-world efficacy from the EoE CONNECT registry. United European Gastroenterol J. 2024 Jun;12(5):585-95. DOI: 10.1002/ueg2.12533
• dc.identifier.doi http://dx.doi.org/10.1002/ueg2.12533
• dc.identifier.issn 2050-6406
• dc.identifier.uri http://hdl.handle.net/10230/70957
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof United European Gastroenterol J. 2024 Jun;12(5):585-95
• dc.rights © 2024 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Budesonide
• dc.subject.keyword Clinical remission
• dc.subject.keyword Dysphagia
• dc.subject.keyword Effectiveness
• dc.subject.keyword Eosinophil count
• dc.subject.keyword Eosinophilic esophagitis
• dc.subject.keyword Fluticasone propionate
• dc.subject.keyword Histological remission
• dc.subject.keyword Orodispersible
• dc.subject.keyword Swallowed topical corticosteroids
• dc.title Swallowed topical corticosteroids for eosinophilic esophagitis: Utilization and real-world efficacy from the EoE CONNECT registry
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion