FOXP2 variation in great ape populations offers insight into the evolution of communication skills

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  • dc.contributor.author Staes, Nickyca
  • dc.contributor.author Sherwood, Chet C.ca
  • dc.contributor.author Wright, Katharineca
  • dc.contributor.author de Manuel, Marcca
  • dc.contributor.author Guevara, Elaine E.ca
  • dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
  • dc.contributor.author Krützen, Michaelca
  • dc.contributor.author Massiah, Michaelca
  • dc.contributor.author Hopkins, William D.ca
  • dc.contributor.author Ely, John J.ca
  • dc.contributor.author Bradley, Brenda J.ca
  • dc.date.accessioned 2018-03-22T12:17:57Z
  • dc.date.available 2018-03-22T12:17:57Z
  • dc.date.issued 2017
  • dc.description.abstract The gene coding for the forkhead box protein P2 (FOXP2) is associated with human language disorders. Evolutionary changes in this gene are hypothesized to have contributed to the emergence of speech and language in the human lineage. Although FOXP2 is highly conserved across most mammals, humans differ at two functional amino acid substitutions from chimpanzees, bonobos and gorillas, with an additional fixed substitution found in orangutans. However, FOXP2 has been characterized in only a small number of apes and no publication to date has examined the degree of natural variation in large samples of unrelated great apes. Here, we analyzed the genetic variation in the FOXP2 coding sequence in 63 chimpanzees, 11 bonobos, 48 gorillas, 37 orangutans and 2 gibbons and observed undescribed variation in great apes. We identified two variable polyglutamine microsatellites in chimpanzees and orangutans and found three nonsynonymous single nucleotide polymorphisms, one in chimpanzees, one in gorillas and one in orangutans with derived allele frequencies of 0.01, 0.26 and 0.29, respectively. Structural and functional protein modeling indicate a biochemical effect of the substitution in orangutans, and because of its presence solely in the Sumatran orangutan species, the mutation may be associated with reported population differences in vocalizations.
  • dc.description.sponsorship This work was partially supported by NIA grant R43-AG17802 to JJE, by MINECO BFU2014-55090-P (FEDER), Howard Hughes International Early Career and Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya to TMB, the James S. McDonnell Foundation (grant 220020293) and by NSF INSPIRE (SMA -1542848) for NS, CCS, WDH and BJB.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Staes N, Sherwood CC, Wright K, de Manuel M, Guevara EE, Marques-Bonet T et al. FOXP2 variation in great ape populations offers insight into the evolution of communication skills. Sci Rep. 2017 Dec 4;7(1):16866. DOI: 10.1038/s41598-017-16844-x
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-16844-x
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/34243
  • dc.language.iso eng
  • dc.publisher Nature Publishing Groupca
  • dc.relation.ispartof Scientific Reports. 2017 Dec 4;7(1):16866
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
  • dc.rights © The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Behavioural genetics
  • dc.subject.keyword Evolutionary genetics
  • dc.title FOXP2 variation in great ape populations offers insight into the evolution of communication skillsca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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