Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI

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• dc.contributor.author Aranha, Mateus Rozalem
• dc.contributor.author González-Ortiz, Sofía
• dc.contributor.author Fortea, Juan
• dc.date.accessioned 2025-02-14T07:06:57Z
• dc.date.available 2025-02-14T07:06:57Z
• dc.date.issued 2024
• dc.description.abstract Background: Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. Methods: We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS. Results: CMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. Discussion: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype. Highlights: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.
• dc.description.sponsorship This study was funded by Alzheimer's Association Research Fellowship to Promote Diversity (AARF-D) Program (AARFD-21-852492) to MRA. It was also supported by the Fondo de Investigaciones Sanitario, Carlos III Health Institute (co-funded by European Regional Development Fund/European Social Fund - A way to make Europe / Investing in your future) (PI20/01473 to JF, PI13/01532, PI16/01825 to RB, PI18/00335 to MCI, PI18/00435 to DA, PI14/1561, PI20/01330 to AL, PI22/00307 to AB), the CIBERNED Program 1, the National Institutes of Health (NIH) (1R01AG056850-01A1; 3RF1AG056850-01S1; AG056850, R21AG056974, and R01AG061566 to JF), the Departament de Salut de la Generalitat de Catalunya, Fundación Tatiana Pérez de Guzmán el Bueno (IIBSP-DOW-2020-151 to JF), the European Union's Horizon 2020, “MES-CoBraD” (H2020-SC1-BHC-2018-2020 / GA 965422 to JF), Brightfocus, and Life Molecular Imaging (LMI) to JF. AB acknowledges support from a Miguel Servet grant (CP20/00038) from the Carlos III Health Institute. and the Alzheimer's Association (AARG-22-923680). MCI acknowledges support from the Alzheimer's Association and Global Brain Health Institute (GBHI_ALZ-18-543740), the Jérôme Lejeune Foundation (#1913 Cycle 2019B), and the Societat Catalana de Neurologia (Premi Beca Fundació SCN 2020). VM acknowledges support from Predoctoral grants from the Carlos III Health Institute (FI18/00275). JA was supported by the Río Hortega Fellowship from Carlos III Health Institute (CM21/00243). The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit for publication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Aranha MR, Montal V, van den Brink H, Pegueroles J, Carmona-Iragui M, Videla L, et al. Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI. Alzheimers Dement. 2024 Jun;20(6):3906-17. DOI: 10.1002/alz.13797
• dc.identifier.doi http://dx.doi.org/10.1002/alz.13797
• dc.identifier.issn 1552-5260
• dc.identifier.uri http://hdl.handle.net/10230/69608
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Alzheimers Dement. 2024 Jun;20(6):3906-17
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/965422
• dc.rights © 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Alzheimer's disease
• dc.subject.keyword Down syndrome
• dc.subject.keyword Cerebral amyloid angiopathy
• dc.subject.keyword Cerebral microbleeds
• dc.subject.keyword Cortical microinfarcts
• dc.subject.keyword Magnetic resonance imaging
• dc.subject.keyword Neuroimaging
• dc.subject.keyword Small vessel diseases
• dc.title Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion