Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)

Triebner, Kai; Bifulco, Ersilia; Barrera Gómez, Jose; Basagaña Flores, Xavier; Benediktsdóttir, Bryndís; Forsberg, Bertil; Franklin, Karl; Garcia-Larsen, Vanessa; Leynaert, Bénédicte; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren-Agirre, Nerea; Pin, Isabelle; Raherison, Chantal; Pereira-Vega, Antonio; Schlünssen, Vivi; Valentín, Antònia; Hustad, Steinar; Gómez Real, Francisco; Dadvand, Payam

Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)

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dc.contributor.author Triebner, Kai
dc.contributor.author Bifulco, Ersilia
dc.contributor.author Barrera Gómez, Jose
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Benediktsdóttir, Bryndís
dc.contributor.author Forsberg, Bertil
dc.contributor.author Franklin, Karl
dc.contributor.author Garcia-Larsen, Vanessa
dc.contributor.author Leynaert, Bénédicte
dc.contributor.author Lindberg, Eva
dc.contributor.author Martínez-Moratalla, Jesús
dc.contributor.author Muniozguren-Agirre, Nerea
dc.contributor.author Pin, Isabelle
dc.contributor.author Raherison, Chantal
dc.contributor.author Pereira-Vega, Antonio
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Valentín, Antònia
dc.contributor.author Hustad, Steinar
dc.contributor.author Gómez Real, Francisco
dc.contributor.author Dadvand, Payam
dc.date.accessioned 2022-05-27T05:50:53Z
dc.date.available 2022-05-27T05:50:53Z
dc.date.issued 2021
dc.description.abstract Background: Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites are associated with higher or lower concentrations of estrogens and may thus alter the female sex hormone balance. Objective: To study whether exposure to UVR, as a modifiable lifestyle factor, is associated with levels of sex hormones (17β-estradiol, estrone, estrone 3-sulfate, testosterone, dehydroepiandrosterone sulfate), gonadotropins (follicle stimulating hormone, luteinizing hormone) as well as sex hormone binding globulin in postmenopausal women, and thus investigate whether managing UVR exposure can influence the hormone balance, with potential benefits for the biological aging process. Methods: The study included 580 postmenopausal women from six European countries, participating in the European Community Respiratory Health Survey (2010-2014). Average UVR exposure during the month before blood sampling was estimated based on personal sun behavior and ambient levels. Hormone concentrations were measured in serum using state-of-the-art methods. Subsequently we applied linear mixed-effects models, including center as random intercept, hormone concentrations (one at a time) as outcome and UVR, age, skin type, body mass index, vitamin D from dietary sources, smoking, age at completed full-time education and season of blood sampling as fixed-effect predictors. Results: One interquartile range increase in UVR exposure was associated with decreased levels of 17β-estradiol (-15.6 pmol/L, 95 % Confidence Interval (CI): -27.69, -3.51) and estrone (-13.36 pmol/L, 95 % CI: -26.04, -0.68) and increased levels of follicle stimulating hormone (9.34IU/L, 95 % CI: 2.91, 15.77) and luteinizing hormone (13.86 IU/daL, 95 % CI: 2.48, 25.25). Conclusions: Exposure to UVR is associated with decreased estrogens and increased gonadotropins in postmenopausal women, a status associated with osteoporosis, lung function decline and other adverse health effects. This study indicates that managing UVR exposure has potential to influence the hormone balance and counteract adverse health conditions after menopause.
dc.format.mimetype application/pdf
dc.identifier.citation Triebner K, Bifulco E, Barrera-Gómez J, Basagaña X, Benediktsdóttir B, Forsberg B, Franklin KA, Garcia-Larsen V, Leynaert B, Lindberg E, Martínez-Moratalla J, Muniozguren-Agirre N, Pin I, Raherison C, Pereira-Vega A, Schlünssen V, Valentin A, Hustad S, Real FG, Dadvand P. Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS). Maturitas. 2021 Mar;145:49-55. DOI: 10.1016/j.maturitas.2020.12.011
dc.identifier.doi http://dx.doi.org/10.1016/j.maturitas.2020.12.011
dc.identifier.issn 0378-5122
dc.identifier.uri http://hdl.handle.net/10230/53280
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Maturitas. 2021 Mar;145:49-55
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Estrogens
dc.subject.keyword Menopause
dc.subject.keyword Reproductive aging
dc.subject.keyword Sunlight
dc.subject.keyword Vitamin D
dc.title Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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