Association of segment-specific pulse wave velocity with vascular calcification: The ARIC (Atherosclerosis Risk in Communities) study
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- dc.contributor.author Ejiri, Kentaro
- dc.contributor.author Ding, Ning
- dc.contributor.author Kim, Esther
- dc.contributor.author Honda, Yasuyuki
- dc.contributor.author Cainzos-Achirica, Miguel
- dc.contributor.author Tanaka, Hirofumi
- dc.contributor.author Howard-Claudio, Candace M.
- dc.contributor.author Butler, Kenneth R.
- dc.contributor.author Hughes, Timothy M.
- dc.contributor.author Van't Hof, Jeremy R.
- dc.contributor.author Meyer, Michelle L.
- dc.contributor.author Blaha, Michael J.
- dc.contributor.author Matsushita, Kunihiro
- dc.date.accessioned 2024-10-28T07:21:15Z
- dc.date.available 2024-10-28T07:21:15Z
- dc.date.issued 2024
- dc.description.abstract Background: Pulse wave velocity (PWV) is a noninvasive measure of arterial stiffness and predictor of cardiovascular disease. However, the association between PWV and vascular calcification across different vascular beds has not been fully investigated. This study aimed to quantify the association between PWV and multiterritory calcification and to explore whether PWV can identify individuals with vascular calcification beyond traditional risk factors. Methods and results: Among 1351 older adults (mean age, 79.2 years [SD, 4.1]) from the ARIC (Atherosclerosis Risk in Communities) study, we measured segment-specific PWVs: heart-carotid, heart-femoral, carotid-femoral, heart-ankle, brachial-ankle, and femoral-ankle. Dependent variables were high calcium score (≥75th percentile of Agatston score) across different vascular beds: coronary arteries, aortic valve ring, aortic valve, mitral valve, ascending aorta, and descending aorta. Quartiles of carotid-femoral, heart-femoral, heart-ankle, and brachial-ankle PWV were significantly associated with coronary artery calcium (eg, adjusted odds ratio [OR] for the highest versus lowest quartile of carotid-femoral PWV, 1.84 [95% CI, 1.24-2.74]). Overall, PWVs were most strongly associated with descending aorta calcification, with significant results for carotid-femoral, heart-femoral, heart-ankle, and brachial-ankle PWV (eg, adjusted OR for the highest versus lowest quartile of carotid-femoral PWV, 3.99 [95% CI, 2.61-6.17]). In contrast, femoral-ankle PWV was inversely associated with descending aorta calcification. Some PWVs improved the discrimination of coronary artery calcium and descending aorta calcification beyond traditional risk factors. Conclusions: The associations of PWV with vascular calcification varied substantially across segments, with descending aorta calcification most closely linked to PWVs. Our study suggests that some PWVs, especially carotid-femoral PWV, are helpful to identify individuals with coronary artery calcium and descending aorta calcification.
- dc.format.mimetype application/pdf
- dc.identifier.citation Ejiri K, Ding N, Kim E, Honda Y, Cainzos-Achirica M, Tanaka H, et al. Association of segment-specific pulse wave velocity with vascular calcification: The ARIC (Atherosclerosis Risk in Communities) study. J Am Heart Assoc. 2024 Jan 16;13(2):e031778. DOI: 10.1161/JAHA.123.031778
- dc.identifier.doi http://dx.doi.org/10.1161/JAHA.123.031778
- dc.identifier.issn 2047-9980
- dc.identifier.uri http://hdl.handle.net/10230/68361
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof J Am Heart Assoc. 2024 Jan 16;13(2):e031778
- dc.rights © 2024 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Aortic calcification
- dc.subject.keyword Arterial stiffness
- dc.subject.keyword Computed tomography
- dc.subject.keyword Coronary artery calcium
- dc.subject.keyword Pulse wave velocity
- dc.subject.keyword Valvular calcification
- dc.subject.keyword Vascular calcification
- dc.title Association of segment-specific pulse wave velocity with vascular calcification: The ARIC (Atherosclerosis Risk in Communities) study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion