Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period

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  • dc.contributor.author Ferránzez Quirante, Olivia
  • dc.contributor.author Grau Cerrato, Santiago
  • dc.contributor.author Urbina, Olatz
  • dc.contributor.author Mojal, Sergio
  • dc.contributor.author Riu Camps, Marta
  • dc.contributor.author Salas Sanchez, Esther
  • dc.date.accessioned 2019-07-16T07:30:14Z
  • dc.date.available 2019-07-16T07:30:14Z
  • dc.date.issued 2018
  • dc.description.abstract OBJECTIVE: Drug-related problems (DRP) produce high morbidity and mortality. It is therefore essential to identify patients at higher risk of these events. This study aimed to validate a DRP risk score in a large number of inpatients. MATERIAL AND METHODS: Validation of a previously designed score to identify inpatients at risk of experiencing at least one DRP in a tertiary university hospital from 2010 to 2013. DRP were detected by a pharmacy warning system integrated in the electronic medical record. The score included the following variables associated with a higher risk of DRP: prescription of a higher number of drugs, greater comorbidity, advanced age, specific ATC groups and certain major diagnostic categories. RESULTS: The study included a total of 52,987 admissions; of these, at least one DRP occurred in 14.9%. After validation of the score (period range, 2010-2013: 0.746-0.764), the area under the curve (AUC) was 0.751 (95% CI: 0.745-0.756). CONCLUSIONS: This value is higher than those reported in other studies describing validation of risk scores. The score showed good capacity to identify those patients at higher risk of DRP in a much larger sample of inpatients than previously described in the literature. This tool allows optimization of drug therapy monitoring in admitted patients.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Ferrández O, Grau S, Urbina O, Mojal S, Riu M, Salas E. Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period. Saudi Pharm J. 2018 Jul;26(5):703-708. DOI: 10.1016/j.jsps.2018.02.020
  • dc.identifier.doi http://dx.doi.org/10.1016/j.jsps.2018.02.020
  • dc.identifier.issn 1319-0164
  • dc.identifier.uri http://hdl.handle.net/10230/41999
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.rights 1319-0164/2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Computerized medical record system
  • dc.subject.keyword Computerized physician order entry
  • dc.subject.keyword Drug-related problems
  • dc.subject.keyword Patient safety
  • dc.subject.keyword Risk score
  • dc.title Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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