Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19

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• dc.contributor.author Dobaño, Carlota
• dc.contributor.author Ramírez-Morros, Anna
• dc.contributor.author Alonso, Selena
• dc.contributor.author Vidal Alaball, Josep
• dc.contributor.author Ruiz-Olalla, Gemma
• dc.contributor.author Vidal, Marta
• dc.contributor.author Rubio, Rocío
• dc.contributor.author Cascant, Emma
• dc.contributor.author Parras, Daniel
• dc.contributor.author Rodrigo Melero, Natalia
• dc.contributor.author Serra, Pau
• dc.contributor.author Carolis, Carlo
• dc.contributor.author Santamaria, Pere
• dc.contributor.author Forcada, Anna
• dc.contributor.author Mendioroz, Jacobo
• dc.contributor.author Aguilar, Ruth
• dc.contributor.author Moncunill, Gemma
• dc.contributor.author Ruiz-Comellas, Anna
• dc.date.accessioned 2021-11-17T07:39:39Z
• dc.date.available 2021-11-17T07:39:39Z
• dc.date.issued 2021
• dc.description.abstract We assessed the duration and baseline determinants of antibody responses to SARS-CoV-2 spike antigens and the occurrence of reinfections in a prospective cohort of 173 Spanish primary health care worker patients followed initially for 9 months and subsequently up to 12.5 months after COVID-19 symptoms onset. Seropositivity to SARS-CoV-2 spike and receptor-binding domain antigens up to 149-270 days was 92.49% (90.17% IgG, 76.3% IgA, 60.69% IgM). In a subset of 64 health care workers who had not yet been vaccinated by April 2021, seropositivity was 96.88% (95.31% IgG, 82.81% IgA) up to 322-379 days post symptoms onset. Four suspected reinfections were detected by passive case detection, two among seronegative individuals (5 and 7 months after the first episode), and one low antibody responder. Antibody levels significantly correlated with fever, hospitalization, anosmia/hypogeusia, allergies, smoking, and occupation. Stable sustainment of IgG responses raises hope for long-lasting COVID-19 vaccine immunity.
• dc.format.mimetype application/pdf
• dc.identifier.citation Dobaño C, Ramírez-Morros A, Alonso S, Vidal-Alaball J, Ruiz-Olalla G, Vidal M, Rubio R, Cascant E, Parras D, Rodrigo Melero N, Serra P, Carolis C, Santamaria P, Forcada A, Mendioroz J, Aguilar R, Moncunill G, Ruiz-Comellas A. Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19. BMC Med. 2021;19(1):155. DOI: 10.1186/s12916-021-02032-2
• dc.identifier.doi http://dx.doi.org/10.1186/s12916-021-02032-2
• dc.identifier.issn 1741-7015
• dc.identifier.uri http://hdl.handle.net/10230/49000
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof BMC Med. 2021;19(1):155
• dc.rights © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Antibodies
• dc.subject.keyword Baseline determinants
• dc.subject.keyword COVID-19
• dc.subject.keyword Cohort
• dc.subject.keyword Duration
• dc.subject.keyword Health care workers
• dc.subject.keyword Kinetics
• dc.subject.keyword Reinfection
• dc.subject.keyword SARS-CoV-2
• dc.subject.keyword Spike antigen
• dc.title Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion