The wiring diagram of a glomerular olfactory system

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• dc.contributor.author Berck, Matthew E.ca
• dc.contributor.author Khandelwal, Avinash, 1987-ca
• dc.contributor.author Claus, Lindseyca
• dc.contributor.author Hernandez-Nunez, Luizca
• dc.contributor.author Si, Guangweica
• dc.contributor.author Tabone, Christopher J.ca
• dc.contributor.author Li, Fengca
• dc.contributor.author Truman, James W.ca
• dc.contributor.author Fetter, Rick D.ca
• dc.contributor.author Louis, Matthieuca
• dc.contributor.author Samuel, Aravinthan D. T.ca
• dc.contributor.author Cardona, Albertca
• dc.date.accessioned 2017-01-16T12:00:15Z
• dc.date.available 2017-01-16T12:00:15Z
• dc.date.issued 2016ca
• dc.description.abstract The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior.
• dc.description.sponsorship This project was supported by the Spanish Ministry of Economy and Competitiveness, ‘Centro de Excelencia Severo Ochoa 2013-2017’, SEV-2012-0208 and grants MICINN BFU2011-26208. AK acknowledges the support of the ‘laCaixa’ International PhD programme.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Berck ME, Khandelwal A, Claus L, Hernandez-Nunez L, Si G, Tabone CJ, Li F, Truman JW, Fetter RD, Louis M, Samuel ADT, Cardona A. The wiring diagram of a glomerular olfactory system. eLife. 2016; 5: e14859. DOI: 10.7554/eLife.14859ca
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.14859
• dc.identifier.issn 2050-084Xca
• dc.identifier.uri http://hdl.handle.net/10230/27903
• dc.language.iso engca
• dc.publisher eLifeca
• dc.relation.ispartof eLife. 2016; 5: e14859
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV2012-0208
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26208
• dc.rights © Copyright Berck et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Connectomics
• dc.subject.keyword D. melanogaster
• dc.subject.keyword Drosophila
• dc.subject.keyword Electron microscopy
• dc.subject.keyword Neural circuits
• dc.subject.keyword Olfaction
• dc.title The wiring diagram of a glomerular olfactory systemca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca