Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Pérez Jurado, Luis Alberto
  • dc.contributor.author Cáceres, Alejandro
  • dc.contributor.author Balagué-Dobón, Laura
  • dc.contributor.author Esko, Tõnu
  • dc.contributor.author López de Heredia, Miguel de
  • dc.contributor.author Quintela Garcia, Ines
  • dc.contributor.author Cruz, Raquel
  • dc.contributor.author Lapunzina, Pablo Daniel
  • dc.contributor.author Carracedo, Ángel
  • dc.contributor.author SCOURGE Cohort Group
  • dc.contributor.author González, Juan Ramón
  • dc.date.accessioned 2024-04-16T06:28:26Z
  • dc.date.available 2024-04-16T06:28:26Z
  • dc.date.issued 2024
  • dc.description.abstract The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.
  • dc.description.sponsorship The authors acknowledge support from the Catalan Department of Economy and Knowledge (SGR2017/1974, SGR2017/801), the Spanish Ministry of Science “Programa de Excelencia María de Maeztu” (MDM-2014-0370) and “Centro de Excelencia Severo Ochoa” (CEX2018-000806-S), the Fondo Europeo de Desarrollo Regional, UE (RTI2018-100789-B-I00) and the Estonian Research Council (PUT1660). The SCOURGE study has been funded by Instituto de Salud Carlos III (COV20_00622) and ofounded by European Union (ERDF) “A way of making Europe”; additional funding was received from Amancio Ortega Foundation and Banco de Santander. Authors also receive support from the Generalitat de Catalunya through the CERCA Program.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pérez-Jurado LA, Cáceres A, Balagué-Dobón L, Esko T, López de Heredia M, Quintela I, et al. Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2. Commun Biol. 2024 Feb 19;7(1):202. DOI: 10.1038/s42003-024-05805-6
  • dc.identifier.doi http://dx.doi.org/10.1038/s42003-024-05805-6
  • dc.identifier.issn 2399-3642
  • dc.identifier.uri http://hdl.handle.net/10230/59778
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Commun Biol. 2024 Feb 19;7(1):202
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-100789-B-I00
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Genetics research
  • dc.subject.keyword Infectious diseases
  • dc.subject.keyword Molecular medicine
  • dc.title Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Hospital del Mar Research Institute)