N-of-1 clinical trials in nutritional interventions directed at improving cognitive function

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• dc.contributor.author Soldevila-Domenech, Natalia
• dc.contributor.author Boronat Rigol, Anna, 1990-
• dc.contributor.author Langohr, Klaus
• dc.contributor.author Torre Fornell, Rafael de la
• dc.date.accessioned 2019-10-08T14:08:22Z
• dc.date.available 2019-10-08T14:08:22Z
• dc.date.issued 2019
• dc.description.abstract Longer life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent a research priority. A large body of evidence suggests that nutrition is involved in the pathogenesis of age-related cognitive decline, but also that it may play a critical role in slowing down its progression. At a population level, healthy dietary patterns interventions, such as the Mediterranean and the MIND diets, have been associated with improved cognitive performance and a decreased risk of neurodegenerative disease development. In the era of evidence-based medicine and patient-centered healthcare, personalized nutritional recommendations would offer a considerable opportunity in preventing cognitive decline progression. N-of-1 clinical trials have emerged as a fundamental design in evidence-based medicine. They consider each individual as the only unit of observation and intervention. The aggregation of series of N-of-1 clinical trials also enables population-level conclusions. This review provides a general view of the current scientific evidence regarding nutrition and cognitive decline, and critically states its limitations when translating results into the clinical practice. Furthermore, we suggest methodological strategies to develop N-of-1 clinical trials focused on nutrition and cognition in an older population. Finally, we evaluate the potential challenges that researchers may face when performing studies in precision nutrition and cognition.
• dc.format.mimetype application/pdf
• dc.identifier.citation Soldevila-Domenech N, Boronat A, Langohr K, de la Torre R. N-of-1 clinical trials in nutritional interventions directed at improving cognitive function. Front Nutr. 2019;6:110. DOI: 10.3389/fnut.2019.00110
• dc.identifier.doi http://dx.doi.org/10.3389/fnut.2019.00110
• dc.identifier.issn 2296-861X
• dc.identifier.uri http://hdl.handle.net/10230/42407
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Nutrition. 2019;6:110
• dc.rights © 2019 Soldevila-Domenech, Boronat, Langohr and de la Torre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword N-of-1
• dc.subject.keyword Personalized nutrition
• dc.subject.keyword Prevention
• dc.subject.keyword Alzheimer's disease
• dc.subject.keyword Multimodal interventions
• dc.subject.keyword Cognition
• dc.subject.keyword Cognitive decline
• dc.title N-of-1 clinical trials in nutritional interventions directed at improving cognitive function
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion