Urban environment during pregnancy and lung function, wheezing, and asthma in school-age children. The generation R study

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• dc.contributor.author Abellan, Alicia
• dc.contributor.author Warembourg, Charline
• dc.contributor.author Mensink-Bout, Sara M.
• dc.contributor.author Ambrós, Albert
• dc.contributor.author Castro, Montserrat de
• dc.contributor.author Fossati, Serena
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Jaddoe, Vincent W. V.
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Santos, Susana
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Duijts, Liesbeth
• dc.date.accessioned 2024-06-27T14:27:18Z
• dc.date.available 2024-06-27T14:27:18Z
• dc.date.issued 2024
• dc.description.abstract The urban environment during pregnancy may influence child's respiratory health, but scarce evidence exists on systematic evaluation of multiple urban exposures (e.g., air pollution, natural spaces, noise, built environment) on children's lung function, wheezing, and asthma development. We aimed to examine the association of the urban environment during pregnancy with lung function, preschool wheezing, and school-age asthma. We included 5624 mother-child pairs participating in a population-based prospective birth cohort. We estimated 30 urban environmental exposures including air pollution, road traffic noise, traffic, green spaces, blue spaces, and built environment during pregnancy. At 10 years of age, lung function was measured by spirometry. Information on preschool wheezing and physician-diagnosed school-age asthma was obtained from multiple questionnaires. We described single-exposure associations with respiratory outcomes using an exposome-wide association study. We also identified patterns of urban exposures with hierarchical clustering on principal components analysis and examined their associations with respiratory outcomes using multivariate regression models. Single-exposure analyses showed associations of higher particulate matter (PM) with lower mid-expiratory flow (FEF25-75%) (e.g., for PM < 2.5 μm of diameter [PM2.5] z-score = -0.06 [-0.09, -0.03]) and higher forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) (e.g., for PM2.5 FEV1 0.05 [0.02, 0.08]) after correction for multiple-hypothesis testing. Cluster analysis described three patterns of urban exposures during pregnancy and showed that the cluster characterised by higher levels of air pollution, noise, walkability, street connectivity, and lower levels of natural spaces were associated with lower FEF25-75% (-0.08 [-0.17, 0.00]), and higher odds of preschool wheezing (1.21 [1.03, 1.43]). This study shows that the characteristics of the urban environment during pregnancy are of relevance to the offspring's respiratory health during childhood.
• dc.description.sponsorship The Generation R Study is made possible by financial support from the Erasmus Medical Centre, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. Dr Vincent Jaddoe received an additional grant from the Netherlands Organization for Health Research and Development (ZonMw-VIDI). This project received funding from the European Union's Horizon 2020 research and innovation programmes (LIFECYCLE, grant agreement No 733206, 2016; EUCAN-Connect No 824989, grant agreement no; ATHLETE, grant agreement No 874583), and from the Spanish Instituto de Salud Carlos III (PI17/01340). The geocodification of the addresses of the study participants and the air pollution estimates were done within the framework of the APACHE project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201). The researchers are independent from the funders. Alicia Abellan holds a LifeCycle fellowship, funded from the European Union's Horizon 2020 research and innovation programme under grant agreement No 733206. Maribel Casas and Mònica Guxens hold a Miguel Servet fellowship (CP16/00128, CPII18/00018) funded by Instituto de Salud Carlos III and cofounded by the European Social Fund “Investing in your future”. Susana Santos is supported by the European Union′s Horizon Europe Research and Innovation Programme under the Marie Sklodowska-Curie Postdoctoral Fellowship Grant Agreement No. 101109136 (URBANE). We acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and support from the Generalitat de Catalunya through the CERCA Program. The study sponsors had no role in the study design, data analysis, interpretation of data, or writing of this report.
• dc.format.mimetype application/pdf
• dc.identifier.citation Abellan A, Warembourg C, Mensink-Bout SM, Ambros A, de Castro M, Fossati S, et al. Urban environment during pregnancy and lung function, wheezing, and asthma in school-age children. The generation R study. Environ Pollut. 2024 Mar 1;344:123345. DOI: 10.1016/j.envpol.2024.123345
• dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2024.123345
• dc.identifier.issn 0269-7491
• dc.identifier.uri http://hdl.handle.net/10230/60604
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Pollut. 2024 Mar 1;344:123345
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101109136
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Asthma
• dc.subject.keyword Cohort study
• dc.subject.keyword Lung function
• dc.subject.keyword Pregnancy
• dc.subject.keyword Urban environment
• dc.subject.keyword Wheezing
• dc.title Urban environment during pregnancy and lung function, wheezing, and asthma in school-age children. The generation R study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion