Occupational exposure to extremely low-frequency magnetic fields and follicular lymphoma risk: a family case-control study

Odutola, Michael K.; van Leeuwen, Marina T.; Bruinsma, Fiona J.; Benke, Geza; Turner, Michelle C.; Trotman, Judith; Turner, Jennifer; Seymour, John F.; Prince, H. Miles; Milliken, Samuel T.; Tiley, Campbell; Hertzberg, Mark; Roncolato, Fernando; Opat, Stephen; Lindeman, Robert; Verner, Emma; Underhill, Craig R.; Cardis, Elisabeth; Giles, Graham; Vajdic, Claire M.

Occupational exposure to extremely low-frequency magnetic fields and follicular lymphoma risk: a family case-control study

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Odutola, Michael K.
dc.contributor.author van Leeuwen, Marina T.
dc.contributor.author Bruinsma, Fiona J.
dc.contributor.author Benke, Geza
dc.contributor.author Turner, Michelle C.
dc.contributor.author Trotman, Judith
dc.contributor.author Turner, Jennifer
dc.contributor.author Seymour, John F.
dc.contributor.author Prince, H. Miles
dc.contributor.author Milliken, Samuel T.
dc.contributor.author Tiley, Campbell
dc.contributor.author Hertzberg, Mark
dc.contributor.author Roncolato, Fernando
dc.contributor.author Opat, Stephen
dc.contributor.author Lindeman, Robert
dc.contributor.author Verner, Emma
dc.contributor.author Underhill, Craig R.
dc.contributor.author Cardis, Elisabeth
dc.contributor.author Giles, Graham
dc.contributor.author Vajdic, Claire M.
dc.date.accessioned 2024-01-17T08:22:32Z
dc.date.available 2024-01-17T08:22:32Z
dc.date.issued 2023
dc.description.abstract Objectives: We aimed to examine the relationship between occupational exposure to extremely low-frequency magnetic fields (ELF-MFs) and follicular lymphoma (FL) risk. Methods: We conducted a family case-control study between 2011 and 2016 in Australia and included 681 cases. Controls were either a family member of cases (related (n=294), unrelated (n=179)) or were unrelated recruited for a similarly designed Australian multiple myeloma study (n=711). We obtained detailed job histories using lifetime work calendars. We assigned exposure to ELF-MFs using an enhanced job exposure matrix, with a lag period of 10 years. We examined associations with FL risk using logistic regression accounting for relatedness between cases and controls. We performed sensitivity analyses including by control type, by sex, complete case analyses, ELF-MF exposure percentiles in addition to quartiles, ELF-MF exposure in the maximum exposed job, a shorter lag period (1 year) and the cumulative exposure in the most recent time period (1-9 years). Results: We observed no association with the average intensity, duration or lifetime cumulative exposure to occupational ELF-MF exposure in the primary or sensitivity analyses. Conclusions: Our findings do not support an association between occupational ELF-MF exposure and FL risk. Although the inclusion of family members as part of the larger control group may have biased our risk estimates towards the null, findings were similar in sensitivity analyses restricted to cases and unrelated controls. Further research incorporating enhanced exposure assessment to ELF-MF is warranted to inform occupational safety regulations and any potential role in lymphomagenesis.
dc.description.sponsorship This study was supported by the National Health and Medical Research Council of Australia (ID 1006707). The National Health and Medical Research Council also supported MTvL (ID 1012141). MKO is supported by an International Postgraduate Award Scholarship through the Australian Government Research Training Program (ID 5188838) and a Cancer Institute NSW Translational Cancer Research Network PhD Scholarship Top-up award. MCT is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by the European Social Fund. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019–2023' Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The INTEROCC Study was supported by the NIH (grant no. 1R01CA124759).
dc.format.mimetype application/pdf
dc.identifier.citation Odutola MK, van Leeuwen MT, Bruinsma FJ, Benke G, Turner MC, Trotman J, Turner J, Seymour JF, Prince HM, Milliken ST, Tiley C, Hertzberg M, Roncolato F, Opat S, Lindeman R, Verner E, Underhill CR, Cardis E, Giles G, Vajdic CM. Occupational exposure to extremely low-frequency magnetic fields and follicular lymphoma risk: a family case-control study. Occup Environ Med. 2023 Oct;80(10):599-602. DOI: 10.1136/oemed-2023-108949
dc.identifier.doi http://dx.doi.org/10.1136/oemed-2023-108949
dc.identifier.issn 1351-0711
dc.identifier.uri http://hdl.handle.net/10230/58736
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof Occup Environ Med. 2023 Oct;80(10):599-602
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Epidemiology
dc.subject.keyword Occupational health
dc.subject.keyword Public health
dc.subject.keyword Radiation
dc.subject.keyword Nonionizing
dc.subject.keyword Risk assessment
dc.title Occupational exposure to extremely low-frequency magnetic fields and follicular lymphoma risk: a family case-control study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)