Astrocyte signature in Alzheimer’s disease continuum through a multi-PET tracer imaging perspective

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• dc.contributor.author Fontana, Igor C.
• dc.contributor.author Scarpa, Miriam
• dc.contributor.author Malarte, Mona-Lisa
• dc.contributor.author Rocha, Filipa M.
• dc.contributor.author Ausellé Bosch, Sira
• dc.contributor.author Bluma, Marina
• dc.contributor.author Bucci, Marco
• dc.contributor.author Chiotis, Konstantinos
• dc.contributor.author Kumar, Amit
• dc.contributor.author Nordberg, Agneta
• dc.date.accessioned 2023-09-12T06:16:19Z
• dc.date.available 2023-09-12T06:16:19Z
• dc.date.issued 2023
• dc.description.abstract Reactive astrogliosis is an early event in the continuum of Alzheimer's disease (AD). Current advances in positron emission tomography (PET) imaging provide ways of assessing reactive astrogliosis in the living brain. In this review, we revisit clinical PET imaging and in vitro findings using the multi-tracer approach, and point out that reactive astrogliosis precedes the deposition of Aβ plaques, tau pathology, and neurodegeneration in AD. Furthermore, considering the current view of reactive astrogliosis heterogeneity-more than one subtype of astrocyte involved-in AD, we discuss how astrocytic body fluid biomarkers might fit into trajectories different from that of astrocytic PET imaging. Future research focusing on the development of innovative astrocytic PET radiotracers and fluid biomarkers may provide further insights into the heterogeneity of reactive astrogliosis and improve the detection of AD in its early stages.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fontana IC, Scarpa M, Malarte ML, Rocha FM, Ausellé-Bosch S, Bluma M, Bucci M, Chiotis K, Kumar A, Nordberg A. Astrocyte signature in Alzheimer’s disease continuum through a multi-PET tracer imaging perspective. Cells. 2023;12(11):1469. DOI: 10.3390/cells12111469
• dc.identifier.doi http://dx.doi.org/10.3390/cells12111469
• dc.identifier.issn 2073-4409
• dc.identifier.uri http://hdl.handle.net/10230/57846
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Cells. 2023;12(11):1469
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Alzheimer’s disease
• dc.subject.keyword BU99008
• dc.subject.keyword GFAP
• dc.subject.keyword L-deprenyl
• dc.subject.keyword SMBT-1
• dc.subject.keyword Positron emission tomography
• dc.subject.keyword Reactive astrogliosis
• dc.title Astrocyte signature in Alzheimer’s disease continuum through a multi-PET tracer imaging perspective
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion