Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes

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• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
• dc.contributor.author Pittis, Alexandros, 1982-ca
• dc.date.accessioned 2016-06-08T13:44:32Z
• dc.date.available 2016-06-08T13:44:32Z
• dc.date.issued 2016
• dc.description.abstract A high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the origins and early evolution of the different organelles remains largely elusive. Organellar proteomes are determined through regulated pathways that target proteins produced in the cytosol to their final subcellular destinations. This internal sorting of proteins can vary across different physiological conditions, cell types and lineages. Evolutionary retargeting - the alteration of a subcellular localization of a protein in the course of evolution - has been rampant in eukaryotes and involves any possible combination of organelles. This fact adds another layer of difficulty to the reconstruction of the origins and evolution of organelles. In this review we discuss current themes in relation to the origin and evolution of organellar proteomes. Throughout the text, a special focus is set on the evolution of mitochondrial and peroxisomal proteomes, which are two organelles for which extensive proteomic and evolutionary studies have been performed.ca
• dc.description.sponsorship TG group research is funded in part by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC (Grant Agreement n. ERC-2012-StG-310325).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Gabaldón T, Pittis AA. Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes. Biochimie. 2015; 119(1): 262-268. DOI 10.1016/j.biochi.2015.03.021ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.biochi.2015.03.021
• dc.identifier.issn 0300-9084
• dc.identifier.uri http://hdl.handle.net/10230/26876
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Biochimie. 2015; 119(1): 262-268
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
• dc.rights © The Authors. Published by Elsevier B.V. /nThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ca
• dc.subject.keyword Compartments
• dc.subject.keyword Eukaryotes
• dc.subject.keyword Evolution
• dc.subject.keyword Organelles
• dc.subject.other Cèl·lules eucariotesca
• dc.title Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotesca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca