Association of exposure to second-hand smoke during childhood with blood DNA methylation

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• dc.contributor.author Cosín Tomàs, Marta
• dc.contributor.author Prado Bert, Paula de
• dc.contributor.author Karachaliou, Marianna
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Pregnancy and Childhood Epigenetics (PACE) consortium
• dc.date.accessioned 2025-02-11T07:21:21Z
• dc.date.available 2025-02-11T07:21:21Z
• dc.date.issued 2024
• dc.description.abstract Introduction: By recent estimates, 40% of children worldwide are exposed to second-hand smoke (SHS), which has been associated with adverse health outcomes. While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm. Methods: Six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium (total N = 2,695), with SHS data and child blood DNAm (aged 7-9 years) measured with the Illumina 450K array were included in the meta-analysis. Linear regression models adjusted for covariates were fitted to examine the association between the number of household smokers in postnatal life (0, 1, 2+) and child blood DNAm. Sensitivity models without adjusting for MSDP and restricted to mothers who did not smoke during pregnancy were evaluated. Results: Our analysis revealed significant associations (False Discovery Rate < 0.05) between household postnatal SHS exposure and DNAm at 11 CpGs in exposed children. Nine CpGs were mapped to genes (MYO1G, FAM184B, CTDSPL2, LTBP3, PDE10A, and FIBCD1), while 2 CpGs were located in open sea regions. Notably, all except 2 CpGs (mapped to FIBCD1 and CTDSPL2) have previously been linked to either personal smoking habits or in utero exposure to smoking. The models restricted to non-smoking mothers provided similar results. Importantly, several of these CpGs and their associated genes are implicated in conditions exacerbated by or directly linked to SHS. Conclusions: Our findings highlight the potential biological effects of SHS on blood DNAm. These findings support further research on epigenetic factors mediating deleterious effects of SHS on child health and call for public health policies aimed at reducing exposure, particularly in environments where children are present.
• dc.description.sponsorship The study is mainly funded by H2020-EU.3.1.2. grant agreement n°874583 (ATHLETE). MCT received a Beatriu de Pinós Postdoctoral Contract awarded by Generalitat-de-Catalunya-AGAUR and EU-H2020 (2019-BP-00107). We acknowledge support from the grant CEX2023-0001290-S funded by MCIN/AEI/ 10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program; the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ZO1 ES49019); the European Union's Horizon 2020 research and innovation program under grant agreements No 733206 (LifeCycle), 874739 (LongITools); and Cancer Research UK [C18281/A29019, EDDISA-Jan22\100003]. Cohort-specific funding can be found in Supplementary Methods. This publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains.
• dc.format.mimetype application/pdf
• dc.identifier.citation Cosin-Tomas M, Hoang T, Qi C, Monasso GS, Langdon R, Kebede Merid S, et al. Association of exposure to second-hand smoke during childhood with blood DNA methylation. Environ Int. 2024 Dec 10;195:109204. DOI: 10.1016/j.envint.2024.109204
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.109204
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/69535
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2024 Dec 10;195:109204
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2023-0001290-S
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874739
• dc.rights © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword 450K array
• dc.subject.keyword Children
• dc.subject.keyword DNA methylation
• dc.subject.keyword Maternal smoking during pregnancy
• dc.subject.keyword Passive smoking
• dc.subject.keyword Postnatal exposure
• dc.subject.keyword Blood DNA methylation
• dc.title Association of exposure to second-hand smoke during childhood with blood DNA methylation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion