Emergence of novel domains in proteins

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• dc.contributor.author Toll i Riera, Macarena, 1984-ca
• dc.contributor.author Albà Soler, Marca
• dc.date.accessioned 2013-11-28T11:32:28Z
• dc.date.available 2013-11-28T11:32:28Z
• dc.date.issued 2013ca
• dc.description.abstract Proteins are composed of a combination of discrete, well-defined, sequence domains, associated with specific functions that have arisen at different times during evolutionary history. The emergence of novel domains is related to protein functional diversification and adaptation. But currently little is known about how novel domains arise and how they subsequently evolve. To gain insights into the impact of recently emerged domains in protein evolution we have identified all human young protein domains that have emerged in approximately the past 550 million years. We have classified them into vertebrate-specific and mammalian-specific groups, and compared them to older domains. We have found 426 different annotated young domains, totalling 995 domain occurrences, which represent about 12.3% of all human domains. We have observed that 61.3% of them arose in newly formed genes, while the remaining 38.7% are found combined with older domains, and have very likely emerged in the context of a previously existing protein. Young domains are preferentially located at the N-terminus of the protein, indicating that, at least in vertebrates, novel functional sequences often emerge there. Furthermore, young domains show significantly higher non-synonymous to synonymous substitution rates than older domains using human and mouse orthologous sequence comparisons. This is also true when we compare young and old domains located in the same protein, suggesting that recently arisen domains tend to evolve in a less constrained manner than older domains. We conclude that proteins tend to gain domains over time, becoming progressively longer. We show that many proteins are made of domains of different age, and that the fastest evolving parts correspond to the domains that have been acquired more recently.en
• dc.description.sponsorship We received financial support from Ministerio de Educación (FPU to M.T.-R.), Ministerio de Innovación y Tecnología grant BIO2009-08160, Ministerio de Economía y Competitividad grant BFU2012-36820, and Institució Catalana de Recerca i Estudis Avançats (ICREA contract to M.M.A.).en
• dc.format.mimetype application/pdfca
• dc.identifier.citation Toll-Riera M, Albà MM. Emergence of novel domains in proteins. BMC Evol. Biol. 2013;13(1):47. DOI: 10.1186/1471-2148-13-47ca
• dc.identifier.doi http://dx.doi.org/10.1186/1471-2148-13-47
• dc.identifier.issn 1471-2148ca
• dc.identifier.uri http://hdl.handle.net/10230/21317
• dc.language.iso engca
• dc.publisher BioMed Centralca
• dc.relation.ispartof BMC Evolutionary Biology. 2013;13(1):47en
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2009-08160
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-36820
• dc.rights © Toll-Riera and Albà. Creative Commons Attribution Licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/2.0/
• dc.subject.keyword Protein domain
• dc.subject.keyword Lineage-specific domain
• dc.subject.keyword Evolutionary rate
• dc.subject.keyword Novel domain
• dc.subject.keyword Gene age
• dc.subject.keyword Domain age
• dc.title Emergence of novel domains in proteinsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca