Role of cannabinoids in alcohol-induced neuroinflammation

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• dc.contributor.author García Baos, Alba
• dc.contributor.author Alegre Zurano, Laia
• dc.contributor.author Cantacorps Centellas, Lídia, 1991-
• dc.contributor.author Martín Sánchez, Ana
• dc.contributor.author Valverde Granados, Olga
• dc.date.accessioned 2022-01-28T08:06:03Z
• dc.date.available 2022-01-28T08:06:03Z
• dc.date.issued 2021
• dc.description.abstract Alcohol is a psychoactive substance highly used worldwide, whose harmful use might cause a broad range of mental and behavioural disorders. Underlying brain impact, the neuroinflammatory response induced by alcohol is recognised as a key contributing factor in the progression of other neuropathological processes, such as neurodegeneration. These sequels are determined by multiple factors, including age of exposure. Strikingly, it seems that the endocannabinoid system modulation could regulate the alcohol-induced neuroinflammation. Although direct CB1 activation can worsen alcohol consequences, targeting other components of the expanded endocannabinoid system may counterbalance the pro-inflammatory response. Indeed, specific modulations of the expanded endocannabinoid system have been proved to exert anti-inflammatory effects, primarily through the CB2 and PPARγ signalling. Among them, some endo- and exogeneous cannabinoids can block certain pro-inflammatory mediators, such as NF-κB, thereby neutralizing the neuroinflammatory intracellular cascades. Furthermore, a number of cannabinoids are able to activate complementary anti-inflammatory pathways, which are necessary for the transition from chronically overactivated microglia to a regenerative microglial phenotype. Thus, cannabinoid modulation provides cooperative anti-inflammatory mechanisms that may be advantageous to resolve a pathological neuroinflammation in an alcohol-dependent context.
• dc.description.sponsorship This study was funded by Ministerio de Economia y Competitividad (grant number SAF2016-75966-R-FEDER), Ministerio de Sanidad (Retic-ISCIII, RD16/017/010 and Plan Nacional sobre Drogas2018/007). This study was funded by FI-AGAUR (grant number 2019FI_B 0008) and by Ministerio de Economía and Competitividad (FPI, grant number BES-2017-080066). The Department of Experimental and Health Sciences (UPF) is an “Unidad de Excelencia María de Maeztu” funded by the MINECO (Ref. MDM-2014-0370).
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Baos A, Alegre-Zurano L, Cantacorps L, Martín-Sánchez A, Valverde O. Role of cannabinoids in alcohol-induced neuroinflammation. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110054. DOI: 10.1016/j.pnpbp.2020.110054
• dc.identifier.doi http://dx.doi.org/10.1016/j.pnpbp.2020.110054
• dc.identifier.issn 0278-5846
• dc.identifier.uri http://hdl.handle.net/10230/52355
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110054
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R-FEDER
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.pnpbp.2020.110054
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Alcohol
• dc.subject.keyword Cannabinoids
• dc.subject.keyword Neuroinflammation
• dc.title Role of cannabinoids in alcohol-induced neuroinflammation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion