Obesity is associated with shorter telomeres in 8 year-old children

Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Gražulevičienė, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine

Obesity is associated with shorter telomeres in 8 year-old children

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dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
dc.contributor.author Maitre, Léa
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Chatzi, Leda
dc.contributor.author Roumeliotaki, Theano
dc.contributor.author Fossati, Serena
dc.contributor.author Gražulevičienė, Regina
dc.contributor.author Gützkow, Kristine B.
dc.contributor.author Lepeule, Johanna
dc.contributor.author Martens, Dries S.
dc.contributor.author McEachan, Rosemary R.C.
dc.contributor.author Meltzer, Helle Margrete
dc.contributor.author Petraviciene, Inga
dc.contributor.author Slama, Rémy
dc.contributor.author Tamayo-Uria, Ibon
dc.contributor.author Urquiza, José M.
dc.contributor.author Vafeiadi, Marina, 1983-
dc.contributor.author Wright, John
dc.contributor.author Nawrot, Tim S.
dc.contributor.author Vrijheid, Martine
dc.date.accessioned 2020-04-08T07:08:38Z
dc.date.available 2020-04-08T07:08:38Z
dc.date.issued 2019
dc.description.abstract Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were used. Maternal pre-pregnancy body mass index (BMI) and 4 adiposity markers in children at age 8 (6-11) years were assessed: BMI, fat mass, waist circumference, and skinfold thickness. Relative LTL was obtained. Associations of LTL with each adiposity marker were calculated using linear mixed models with a random cohort effect. For each 1 kg/m² increment in maternal pre-pregnancy BMI, the child's LTL was 0.23% shorter (95%CI: 0.01,0.46%). Each unit increase in child BMI z-score was associated with 1.21% (95%CI: 0.30,2.11%) shorter LTL. Inverse associations were observed between waist circumference and LTL (-0.96% per z-score unit; 95%CI: -2.06,0.16%), and skinfold thickness and LTL (-0.10% per z-score unit; 95%CI: -0.23,0.02%). In conclusion, this large multicentric study suggests that higher child adiposity indicators are associated with short telomeres in children, and that associations are stronger for child BMI than for maternal pre-pregnancy BMI.
dc.description.sponsorship This work was supported by the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308333 – the HELIX project. INMA data collection was supported by grant C/ from the Instituto de Salud Carlos III. This project has received funding from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No 774548. Tim S. Nawrot was funded by the EU Program “Ideas” (ERC-2012-StG 310898). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. We are grateful to all the participating families in the six countries who took part in this study.
dc.format.mimetype application/pdf
dc.identifier.citation Clemente DBP, Maitre L, Bustamante M, Chatzi L, Roumeliotaki T, Fossati S, Grazuleviciene R, Gützkow KB, Lepeule J, Martens DS, McEachan RRC, Meltzer HM, Petraviciene I, Slama R, Tamayo-Uria I, Urquiza J, Vafeiadi M, Wright J, Nawrot TS, Vrijheid M. Obesity is associated with shorter telomeres in 8 year-old children. Sci Rep. 2019; 9(1):18739. DOI: 10.1038/s41598-019-55283-8
dc.identifier.doi http://dx.doi.org/10.1038/s41598-019-55283-8
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/44185
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2019; 9(1):18739
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/774548
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310898
dc.rights © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Epidemiology
dc.subject.keyword Predictive markers
dc.subject.keyword Risk factors
dc.title Obesity is associated with shorter telomeres in 8 year-old children
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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