The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults
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- dc.contributor.author Siroux, Valérie
- dc.contributor.author Ballardini, Natalia
- dc.contributor.author Soler, M.
- dc.contributor.author Lupinek, Christian
- dc.contributor.author Boudier, Anne
- dc.contributor.author Pin, Isabelle
- dc.contributor.author Just, Jocelyne
- dc.contributor.author Nadif, Rachel
- dc.contributor.author Antó i Boqué, Josep Maria
- dc.contributor.author Melen, E.
- dc.contributor.author Valenta, Rudolf
- dc.contributor.author Wickman, Magnus
- dc.contributor.author Bousquet, Jean
- dc.date.accessioned 2019-01-22T13:45:56Z
- dc.date.issued 2018
- dc.description.abstract Background: Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. Methods: IgE reactivity to 64 micro‐arrayed aeroallergen molecules was determined with the MeDALL‐chip in samples from the French EGEA study (n = 840, age = 40.7 ± 17.1) and the Swedish population‐based birth cohort BAMSE (n = 786, age = 16 ± 0.26). The age‐ and sex‐adjusted associations between the number of IgE‐reactive allergen molecules (≥0.3 ISU) and the asthma‐rhinitis phenotypes were assessed using a negative binomial model. Results: Groups representing 4 phenotypes were identified: no asthma‐no rhinitis (A−R−; 30% in EGEA and 54% in BAMSE), asthma alone (A+R−; 11% and 8%), rhinitis alone (A−R+; 15% and 24%) and asthma‐rhinitis (A+R+; 44% and 14%). The numbers of IgE‐reactive aeroallergen molecules significantly differed between phenotypes (median in A−R−, A+R−, A−R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE). As compared to A−R− subjects, the adjusted ratio of the mean number of IgE‐reactive molecules was higher in A+R+ than in A+R− or A−R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE). Conclusion: The A+R+ phenotype combined the sensitization pattern of both the A−R+ and A+R− phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms.
- dc.format.mimetype application/pdf
- dc.identifier.citation Siroux V, Ballardini N, Soler M, Lupinek C, Boudier A, Pin I et al. The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults. Allergy. 2018;73(7):1447-58. DOI: 10.1111/all.13410
- dc.identifier.doi http://dx.doi.org/10.1111/all.13410
- dc.identifier.issn 0105-4538
- dc.identifier.uri http://hdl.handle.net/10230/36363
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Allergy. 2018;73(7):1447-58
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
- dc.rights This is the peer reviewed version of the following article: Siroux V, Ballardini N, Soler M, Lupinek C, Boudier A, Pin I, Just J, Nadif R, Anto JM, Melen E, Valenta R, Wickman M, Bousquet J. The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults. Allergy. 2018; 73(7):1447-1458. DOI 10.1111/all.13410, which has been published in final form at http://dx.doi.org/10.1111/all.13410. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Allergens
- dc.subject.keyword Epidemiology
- dc.subject.keyword Multimorbidity
- dc.subject.keyword Polysensitization
- dc.subject.keyword Specific IgE
- dc.title The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion