Contribution of evolutionary selected immune gene polymorphism to immune-related disorders: the case of lymphocyte scavenger receptors CD5 and CD6

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Casadó Llombart, Sergi
  • dc.contributor.author Velasco de Andrés, María
  • dc.contributor.author Català, Cristina
  • dc.contributor.author Leyton Pereira, Alejandra
  • dc.contributor.author Lozano, Francisco
  • dc.contributor.author Bosch Fusté, Elena
  • dc.date.accessioned 2021-06-07T07:32:04Z
  • dc.date.available 2021-06-07T07:32:04Z
  • dc.date.issued 2021
  • dc.description.abstract Pathogens are one of the main selective pressures that ancestral humans had to adapt to. Components of the immune response system have been preferential targets of natural selection in response to such pathogen-driven pressure. In turn, there is compelling evidence showing that positively selected immune gene variants conferring increased resistance to past or present infectious agents are today associated with increased risk for autoimmune or inflammatory disorders but decreased risk of cancer, the other side of the same coin. CD5 and CD6 are lymphocytic scavenger receptors at the interphase of the innate and adaptive immune responses since they are involved in both: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by the clonotypic antigen-specific receptor present in T and B cells (TCR and BCR, respectively). Here, we review available information on CD5 and CD6 as targets of natural selection as well as on the role of CD5 and CD6 variation in autoimmunity and cancer.
  • dc.description.sponsorship This research was funded by Spanish Ministerio de Economía y Competitividad (MINECO; SAF-2016-80535-R, PID2019-106658RB-I00 and PCIN-2015-070) co-financed by European Development Regional Fund (ERDF) “A way to achieve Europe”, Agencia Estatal de Investigación (AEI; PID2019-110933GB-I00/AEI/10.13039/501100011033 and CEX2018-000792-M) and Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR; 2017/SGR/1582 and 2017SGR00702) from Generalitat de Catalunya to F.L. and E.B. In addition, S.C.-L., M.V.-d.A., C.C. and A.L.-P. are recipients of fellowships from Ministerio de Educación, Cultura y Deporte (FPU15/02897) MINECO (BES-2014-069237; BES-2017-082107) and Chilean Agencia Nacional de Investigación y Desarrollo (ANID; 2018-72190154), respectively.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Casadó-Llombart S, Velasco-de Andrés M, Català C, Leyton-Pereira A, Lozano F, Bosch E. Contribution of evolutionary selected immune gene polymorphism to immune-related disorders: the case of lymphocyte scavenger receptors CD5 and CD6. Int J Mol Sci. 2021;22(10):5315. DOI: 10.3390/ijms22105315
  • dc.identifier.doi http://dx.doi.org/10.3390/ijms22105315
  • dc.identifier.issn 1422-0067
  • dc.identifier.uri http://hdl.handle.net/10230/47780
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Int J Mol Sci. 2021;22(10):5315
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF-2016-80535-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106658RB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES-2014-069237
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BES-2017-082107
  • dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword CD5
  • dc.subject.keyword CD6
  • dc.subject.keyword Autoimmunity
  • dc.subject.keyword Cancer
  • dc.subject.keyword Human genetics
  • dc.subject.keyword Immune response
  • dc.subject.keyword Infections
  • dc.subject.keyword Natural selection
  • dc.subject.keyword Scavenger receptors
  • dc.subject.keyword Single nucleotide polymorphisms
  • dc.title Contribution of evolutionary selected immune gene polymorphism to immune-related disorders: the case of lymphocyte scavenger receptors CD5 and CD6
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)