Explaining ethnic differentials in COVID-19 mortality: a cohort study

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• dc.contributor.author Batty, G. David
• dc.contributor.author Gaye, Bamba
• dc.contributor.author Gale, Catharine R.
• dc.contributor.author Hamer, Mark
• dc.contributor.author Lassale, Camille
• dc.date.accessioned 2022-05-06T06:46:11Z
• dc.date.available 2022-05-06T06:46:11Z
• dc.date.issued 2022
• dc.description.abstract Ethnic inequalities in coronavirus disease 2019 (COVID-19) hospitalizations and mortality have been widely reported, but there is scant understanding of how they are embodied. The UK Biobank prospective cohort study comprises approximately half a million people who were aged 40-69 years at study induction, between 2006 and 2010, when information on ethnic background and potential explanatory factors was captured. Study members were prospectively linked to a national mortality registry. In an analytical sample of 448,664 individuals (248,820 women), 705 deaths were ascribed to COVID-19 between March 5, 2020, and January 24, 2021. In age- and sex-adjusted analyses, relative to White participants, Black study members experienced approximately 5 times the risk of COVID-19 mortality (odds ratio (OR) = 4.81, 95% confidence interval (CI): 3.28, 7.05), while there was a doubling in the South Asian group (OR = 2.05, 95% CI: 1.30, 3.25). Controlling for baseline comorbidities, social factors (including socioeconomic circumstances), and lifestyle indices attenuated this risk differential by 34% in Black study members (OR = 2.84, 95% CI: 1.91, 4.23) and 37% in South Asian individuals (OR = 1.57, 95% CI: 0.97, 2.55). The residual risk of COVID-19 deaths in ethnic minority groups may be ascribed to a range of unmeasured characteristics and requires further exploration.
• dc.format.mimetype application/pdf
• dc.identifier.citation Batty GD, Gaye B, Gale CR, Hamer M, Lassale C. Explaining ethnic differentials in COVID-19 mortality: a cohort study. Am J Epidemiol. 2022 Jan 24; 191(2): 275-81. DOI: 10.1093/aje/kwab237
• dc.identifier.doi http://dx.doi.org/10.1093/aje/kwab237
• dc.identifier.issn 0002-9262
• dc.identifier.uri http://hdl.handle.net/10230/53010
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof American Journal of Epidemiology. 2022 Jan 24; 191(2): 275-81
• dc.rights Copyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword COVID-19
• dc.subject.keyword Cohort study
• dc.subject.keyword Ethnicity
• dc.title Explaining ethnic differentials in COVID-19 mortality: a cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion