Horizontal acquisition of toxic alkaloid synthesis in a clade of plant associated fungi

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• dc.contributor.author Marcet Houben, Marinaca
• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
• dc.date.accessioned 2016-06-07T13:15:24Z
• dc.date.available 2016-06-07T13:15:24Z
• dc.date.issued 2016
• dc.description.abstract Clavicipitaceae is a fungal group that comprises species that closely interact with plants as pathogens, parasites or symbionts. A key factor in these interactions is the ability of these fungi to synthesize toxic alkaloid compounds that contribute to the protection of the plant host against herbivores. Some of these compounds such as ergot alkaloids are toxic to humans and have caused important epidemics throughout history. The gene clusters encoding the proteins responsible for the synthesis of ergot alkaloids and lolines in Clavicipitaceae have been elucidated. Notably, homologs to these gene clusters can be found in distantly related species such as Aspergillus fumigatus and Penicillium expansum, which diverged from Clavicipitaceae more than 400 million years ago. We here use a phylogenetic approach to analyze the evolution of these gene clusters. We found that the gene clusters conferring the ability to synthesize ergot alkaloids and loline emerged first in Eurotiomycetes and were then likely transferred horizontally to Clavicipitaceae. Horizontal gene transfer is known to play a role in shaping the distribution of secondary metabolism clusters across distantly related fungal species. We propose that HGT events have played an important role in the capability of Clavicipitaceae to produce two key secondary metabolites that have enhanced the ability of these species to protect their plant hosts, therefore favoring their interactions.ca
• dc.description.sponsorship TG group research is funded in part by a grant from the Spanish Ministry of Economy and Competitiveness grants, ‘Centro de Excelencia Severo Ochoa 2013–2017’ SEV-2012-0208, and BIO2012-37161 cofounded by European Regional Development Fund (ERDF), a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC (Grant Agreement no. ERC-2012-StG-310325)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Marcet-Houben M, Gabaldón T. Horizontal acquisition of toxic alkaloid synthesis in a clade of plant associated fungi. Fungal genetics and biology. 2016; 86: 71-80. DOI 10.1016/j.fgb.2015.12.006ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.fgb.2015.12.006
• dc.identifier.issn 1087-1845
• dc.identifier.uri http://hdl.handle.net/10230/26859
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Fungal genetics and biology. 2016; 86: 71-80
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325
• dc.rights © 2015 The Authors. Published by Elsevier Inc./nThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ca
• dc.subject.keyword Clavicipitaceae
• dc.subject.keyword Ergot alkaloids
• dc.subject.keyword HGT
• dc.subject.keyword Loline
• dc.subject.keyword Phylogenetics
• dc.subject.keyword Phylome
• dc.subject.other Filogèniaca
• dc.subject.other Fongsca
• dc.title Horizontal acquisition of toxic alkaloid synthesis in a clade of plant associated fungica
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca