Increased opioid dependence in a mouse model of panic disorder
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Gallego, Xavierca
- dc.contributor.author Murtra, Patriciaca
- dc.contributor.author Zamalloa, Teresaca
- dc.contributor.author Canals, Josep Mariaca
- dc.contributor.author Pineda, Josebaca
- dc.contributor.author Amador Arjona, Alejandroca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Dierssen, Maraca
- dc.date.accessioned 2015-06-08T08:50:00Z
- dc.date.available 2015-06-08T08:50:00Z
- dc.date.issued 2010ca
- dc.description.abstract Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate dependence, using a transgenic mouse model (TgNTRK3). Constitutive TrkC overexpression in TgNTRK3 mice dramatically alters spontaneous firing rates of locus coeruleus (LC) neurons and the response of the noradrenergic system to chronic opiate exposure, possibly related to the altered regulation of neurotrophic peptides observed. Notably, TgNTRK3 LC neurons showed an increased firing rate in saline-treated conditions and profound abnormalities in their response to met5-enkephalin. Behaviorally, chronic morphine administration induced a significantly increased withdrawal syndrome in TgNTRK3 mice. In conclusion, we show here that the NT-3/TrkC system is an important regulator of neuronal firing in LC and could contribute to the adaptations of the noradrenergic system in response to chronic opiate exposure. Moreover, our results indicate that TrkC is involved in the molecular and cellular changes in noradrenergic neurons underlying both panic attacks and opiate dependence and support a functional endogenous opioid deficit in panic disorder patients.en
- dc.description.sponsorship This work was funded by the Spanish Ministry of Education and Sciences SAF2007-31093-E, SAF2007-60827, and SAF2008-03612, 2009SGR1313 and Health (PI082038), Fundación Areces, Marató TV3, Phecomp (EU LSHM-CT-2007-037669; 037627-AnEUploidy), Ministerio de Salud y Consumo (RTA G03/005 and PI05/0513, PI082038), University of the Basque Country (1/UPV 0026.327-E-15924/2004 and GIU07/46), Plan Nacional sobre Drogas (PNDMSC 2005) and CIBERER. Patricia Murtra is a scientific researcher supported by the Juan de la Cierva program of Ministerio de Ciencia y Tecnología. Teresa Zamalloa was supported by a predoctoral fellowship from the Basque Governmenten
- dc.format.mimetype application/pdfca
- dc.identifier.citation Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A et al. Increased opioid dependence in a mouse model of panic disorder. Frontiers in Behavioral Neuroscience. 2010;3:60. DOI: 10.3389/neuro.08.060.2009ca
- dc.identifier.doi http://dx.doi.org/10.3389/neuro.08.060.2009
- dc.identifier.issn 1662-5153ca
- dc.identifier.uri http://hdl.handle.net/10230/23761
- dc.language.iso engca
- dc.publisher Frontiersca
- dc.relation.ispartof Frontiers in Behavioral Neuroscience. 2010;3:60
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/037669ca
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-31093
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-60827
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2008-03612
- dc.rights © 2010 Gallego, Murtra, Zamalloa, Canals, Pineda, Amador-Arjona, Maldonado and Dierssen. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.en
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword TgNTRK3en
- dc.subject.keyword NT-3en
- dc.subject.keyword TrkCen
- dc.subject.keyword BDNFen
- dc.subject.keyword TrkBen
- dc.subject.keyword Panic disorderen
- dc.subject.keyword Opiate withdrawalen
- dc.subject.keyword Locus coeruleusen
- dc.subject.other Hipocamp (Cervell)ca
- dc.subject.other Trastorns de pànic -- Models animalsca
- dc.title Increased opioid dependence in a mouse model of panic disorderen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca