Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status

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  • dc.contributor.author Khoury, Nadine
  • dc.contributor.author Castañer, Olga
  • dc.contributor.author Salas-Salvadó, Jordi
  • dc.date.accessioned 2024-04-10T07:00:49Z
  • dc.date.available 2024-04-10T07:00:49Z
  • dc.date.issued 2023
  • dc.description.abstract Introduction The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.
  • dc.description.sponsorship This study was supported by the official Spanish Institutions for Funding Scientific Biomedical Research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects led by JSS and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, and PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to JS-S; the European Research Council (Advanced Research Grant, 2014–2019; agreement #340918) granted to MM-G; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018); the PROMETEO/21/2021 grant from the Generalitat Valenciana; The Institut de Recerca en Nutrició i Seguretata Alimentaria (INSA-UB). University of Barcelona, Barcelona, Spain, is recognized as a Maria de Maeztu Unit of Excellence grant CEX2021-001234-M) funded by MICIN/AEI/FEDER, UE; the SEMERGEN grant; None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication. JSS senior author, gratefully acknowledges the financial support by ICREA under the ICREA Academia program. NK was funded by a research grant from the Agència de Gestió d’Ajuts Universitaris de Recerca (AGAUR FI, record number: 2021FI_B 00145). MÁ.M was funded by Sara Borrell (CD21/00045).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Khoury N, Martínez MÁ, Paz-Graniel I, Martínez-González MÁ, Corella D, Castañer O, et al. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status. Environ Res. 2023 Jun 15;227:115697. DOI: 10.1016/j.envres.2023.115697
  • dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2023.115697
  • dc.identifier.issn 0013-9351
  • dc.identifier.uri http://hdl.handle.net/10230/59720
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Environ Res. 2023 Jun 15;227:115697
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2021-001234-M
  • dc.rights © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0
  • dc.subject.keyword Polychlorinated dibenzo-p-furans (PCDD/F)
  • dc.subject.keyword Adiposity
  • dc.subject.keyword Obesity
  • dc.subject.keyword Abdominal obesity
  • dc.subject.keyword Endocrine disrupting chemicals
  • dc.title Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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