Cancer evolution: A multifaceted affair

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• dc.contributor.author Ciriello, Giovanni
• dc.contributor.author Magnani, Luca
• dc.contributor.author Aitken, Sarah J.
• dc.contributor.author Akkari, Leila
• dc.contributor.author Behjati, Sam
• dc.contributor.author Hanahan, Douglas
• dc.contributor.author Landau, Dan A.
• dc.contributor.author López Bigas, Núria
• dc.contributor.author Lupiáñez, Darío G.
• dc.contributor.author Marine, Jean-Christophe
• dc.contributor.author Martin-Villalba, Ana
• dc.contributor.author Natoli, Gioacchino
• dc.contributor.author Obenauf, Anna C.
• dc.contributor.author Oricchio, Elisa
• dc.contributor.author Scaffidi, Paola
• dc.contributor.author Sottoriva, Andrea
• dc.contributor.author Swarbrick, Alexander
• dc.contributor.author Tonon, Giovanni
• dc.contributor.author Vanharanta, Sakari
• dc.contributor.author Zuber, Johannes
• dc.date.accessioned 2025-03-28T07:11:24Z
• dc.date.available 2025-03-28T07:11:24Z
• dc.date.issued 2024
• dc.description.abstract Cancer cells adapt and survive through the acquisition and selection of molecular modifications. This process defines cancer evolution. Building on a theoretical framework based on heritable genetic changes has provided insights into the mechanisms supporting cancer evolution. However, cancer hallmarks also emerge via heritable nongenetic mechanisms, including epigenetic and chromatin topological changes, and interactions between tumor cells and the tumor microenvironment. Recent findings on tumor evolutionary mechanisms draw a multifaceted picture where heterogeneous forces interact and influence each other while shaping tumor progression. A comprehensive characterization of the cancer evolutionary toolkit is required to improve personalized medicine and biomarker discovery.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ciriello G, Magnani L, Aitken SJ, Akkari L, Behjati S, Hanahan D, et al. Cancer evolution: A multifaceted affair. Cancer Discov. 2024 Jan 12;14(1):36-48. DOI: 10.1158/2159-8290.CD-23-0530
• dc.identifier.doi http://dx.doi.org/10.1158/2159-8290.CD-23-0530
• dc.identifier.issn 2159-8274
• dc.identifier.uri http://hdl.handle.net/10230/70037
• dc.language.iso eng
• dc.publisher American Association for Cancer Research (AACR)
• dc.relation.ispartof Cancer Discov. 2024 Jan 12;14(1):36-48
• dc.rights © 2023 The Authors; Published by the American Association for Cancer Research This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Càncer
• dc.subject.other Tumors
• dc.title Cancer evolution: A multifaceted affair
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion