Healthcare resource utilization and costs associated with inadequate initial antibiotic treatment of bacteraemia produced by carbapenem-resistant Gram-negative bacilli (CRGNB): a descriptive, observational study in Spanish hospitals

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• dc.contributor.author Garnacho Montero, José
• dc.contributor.author Aguado, José María
• dc.contributor.author Alemparte, Enrique
• dc.contributor.author Horcajada Gallego, Juan Pablo
• dc.contributor.author López-Medrano, Francisco
• dc.contributor.author Ramirez, Paula
• dc.contributor.author Giró, Ariadna
• dc.contributor.author Blasco, Martí
• dc.contributor.author Suberviola, Borja
• dc.date.accessioned 2025-07-25T06:17:34Z
• dc.date.available 2025-07-25T06:17:34Z
• dc.date.issued 2025
• dc.description.abstract Introduction: Carbapenem-resistant gram-negative bacilli (CRGNB) are one of the main causes of nosocomial infections, posing a major public health challenge. Blood stream infections (BSI) require special attention because of the higher morbidity and mortality associated. Objective: To assess the impact of initial adequate or inadequate antibiotic treatment on the length of stay (LOS) and healthcare resource utilisation of patients with bloodstream infections (BSI) caused by a Carbapenem-resistant gram-negative bacilli (CRGNB) in the Spanish clinical practice. Methods: A descriptive, observational, retrospective chart review study of patients diagnosed with CRGNB bacteriemia in 6 Spanish public hospitals. Results: The overall median LOS of the total population (n=64) was 26.5 days (Q1: 16 days; Q3: 40 days). The median LOS for the initially adequately treated group was 27 days (Q1: 17; Q3: 50), and 24 days (Q1: 15; Q3: 38) for the initially inadequately treated (t-test p= 0.5031). In the Hospital Ward group (n=44), initially adequately treated patients spent hospitalised a median of 6 days less than the initially inadequately treated patients (18 days [Q1: 12; Q3: 27] vs 24 days [Q1: 15; Q3: 38] respectively, p=0.0269). In the total population analysis, initially adequately treated patients had a lower use of resources (20,895.02 [Q1: 11,543.67 ; Q3: 61,773.17 ]) compared to initially inadequately treated patients (24,444.02 [Q1: 11,571.63 ; Q3: 40,790.64 ). Conclusion: Results suggest that inadequate empirical treatment for BSI caused by CRGNB in the hospital ward could be associated with an increase in the LOS and resource utilization of these patients.
• dc.format.mimetype application/pdf
• dc.identifier.citation Garnacho-Montero J, Aguado JM, Alemparte E, Horcajada JP, López-Medrano F, Ramírez P, et al. Healthcare resource utilization and costs associated with inadequate initial antibiotic treatment of bacteraemia produced by carbapenem-resistant Gram-negative bacilli (CRGNB): a descriptive, observational study in Spanish hospitals. Rev Esp Quimioter. 2025 May 14;38(3):197-207. DOI: 10.37201/req/121.2024
• dc.identifier.doi http://dx.doi.org/10.37201/req/121.2024
• dc.identifier.issn 0214-3429
• dc.identifier.uri http://hdl.handle.net/10230/70996
• dc.language.iso eng
• dc.publisher Sociedad Española de Quimioterapia
• dc.relation.ispartof Rev Esp Quimioter. 2025 May 14;38(3):197-207
• dc.rights © 2025 The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/). Published by Index on behalf of the Sociedad Española de Quimioterapia.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Antibiotic treatment adequacy
• dc.subject.keyword Blood stream infections
• dc.subject.keyword Carbapenem-resistant gram-negative bacilli
• dc.subject.keyword Healthcare resource utilization
• dc.subject.keyword Length of stay
• dc.title Healthcare resource utilization and costs associated with inadequate initial antibiotic treatment of bacteraemia produced by carbapenem-resistant Gram-negative bacilli (CRGNB): a descriptive, observational study in Spanish hospitals
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion