Social factors influence behavior in the novel object recognition task in a mouse model of down syndrome

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  • dc.contributor.author Sierra, Cesar
  • dc.contributor.author De Toma, Ilario
  • dc.contributor.author Lo Cascio, Lorenzo
  • dc.contributor.author Vegas, Esteban
  • dc.contributor.author Dierssen, Mara
  • dc.date.accessioned 2022-03-15T07:22:48Z
  • dc.date.available 2022-03-15T07:22:48Z
  • dc.date.issued 2021
  • dc.description.abstract The use of mouse models has revolutionized the field of Down syndrome (DS), increasing our knowledge about neuropathology and helping to propose new therapies for cognitive impairment. However, concerns about the reproducibility of results in mice and their translatability to humans have become a major issue, and controlling for moderators of behavior is essential. Social and environmental factors, the experience of the researcher, and the sex and strain of the animals can all have effects on behavior, and their impact on DS mouse models has not been explored. Here we analyzed the influence of a number of social and environmental factors, usually not taken into consideration, on the behavior of male and female wild-type and trisomic mice (the Ts65Dn model) in one of the most used tests for proving drug effects on memory, the novel object recognition (NOR) test. Using principal component analysis and correlation matrices, we show that the ratio of trisomic mice in the cage, the experience of the experimenter, and the timing of the test have a differential impact on male and female and on wild-type and trisomic behavior. We conclude that although the NOR test is quite robust and less susceptible to environmental influences than expected, to obtain useful results, the phenotype expression must be contrasted against the influences of social and environmental factors.
  • dc.description.sponsorship The lab of MD is supported by the Departament d’Universitats, Recerca i Societat de la Informació de la Generalitat de Catalunya (Grups consolidats 2017 SGR 926, 2017 SGR 138). This research was funded by the Agencia Estatal de Investigación (PID2019-110755RB-I00/AEI/10.13039/501100011033), the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No. 848077. Jerôme Lejeune Foundation (Grant number 2002), NIH (Grant Number: 1R01EB 028159-01), Marató TV3 (#2016/20-30), and JPND (Heroes; AC17/00006). The Centre for Genomic Regulation (CRG) acknowledges the support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Program/Generalitat de Catalunya. The CIBER of Rare Diseases (CIBERER) is an initiative of the ISCIII. CS received the FI grant from Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Sierra C, De Toma I, Lo Cascio L, Vegas E, Dierssen M. Social factors influence behavior in the novel object recognition task in a mouse model of down syndrome. Front Behav Neurosci. 2021 Nov 5;15:772734. DOI: 10.3389/fnbeh.2021.772734
  • dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2021.772734
  • dc.identifier.issn 1662-5153
  • dc.identifier.uri http://hdl.handle.net/10230/52694
  • dc.language.iso eng
  • dc.publisher Frontiers Media
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848077
  • dc.rights © 2021 Cesar Sierra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Down, Síndrome de
  • dc.subject.other Ratolins -- Experiments
  • dc.title Social factors influence behavior in the novel object recognition task in a mouse model of down syndrome
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)
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