Early identification of prolonged QT interval for prevention of sudden infant death

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• dc.contributor.author Sarquella-Brugada, Georgia
• dc.contributor.author Martí Almor, Julio
• dc.contributor.author Campuzano, Oscar
• dc.date.accessioned 2022-06-09T06:53:56Z
• dc.date.available 2022-06-09T06:53:56Z
• dc.date.issued 2021
• dc.description.abstract Introduction: Long QT syndrome is the main arrhythmogenic disease responsible for sudden death in infants, especially in the first days of life. Performing an electrocardiogram in newborns could enable early diagnosis and adoption of therapeutic measures focused on preventing lethal arrhythmogenic events. However, the inclusion of an electrocardiogram in neonatal screening protocols still remains a matter of discussion. To comprehensively analyse the potential clinical value of performing an electrocardiogram and subsequent follow-up in a cohort of newborns. Methods: Electrocardiograms were performed in 685 neonates within the first week of life. One year follow-up was performed if QTc > 450 ms identified. Comprehensive genetic analysis using massive sequencing was performed in all cases with QTc > 470 ms. Results: We identified 54 neonates with QTc > 450 ms/ <470 ms; all normalized QTc values within 6 months. Eight cases had QTc > 480 ms at birth and, if persistent, pharmacological treatment was administrated during follow-up. A rare variant was identified as the potential cause of long QT syndrome in five cases. Three cases showed a family history of sudden arrhythmogenic death. Conclusions: Our prospective study identifies 0.14% of cases with a definite long QT, supporting implementation of electrocardiograms in routine pediatric protocols. It is an effective, simple and non-invasive approach that can help prevent sudden death in neonates and their relatives. Genetic analyses help to unravel the cause of arrhythmogenic disease in diagnosing neonates. Further, clinical assessment and genetic analysis of relatives allowed early identification of family members at risk of arrhythmias helping to adopt preventive personalized measures.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sarquella-Brugada G, García-Algar O, Zambrano MD, Fernández-Falgueres A, Sailer S, Cesar S, et al. Early identification of prolonged QT interval for prevention of sudden infant death. Front Pediatr. 2021 Jul 29; 9: 704580. DOI: 10.3389/fped.2021.704580
• dc.identifier.doi http://dx.doi.org/10.3389/fped.2021.704580
• dc.identifier.issn 2296-2360
• dc.identifier.uri http://hdl.handle.net/10230/53425
• dc.language.iso eng
• dc.publisher Frontiers
• dc.rights Copyright © 2021 Sarquella-Brugada, García-Algar, Zambrano, Fernández-Falgueres, Sailer, Cesar, Sebastiani, Martí-Almor, Aurensanz, Cruzalegui, Merchan, Coll, Pérez-Serra, Olmo, Fiol, Iglesias, Ferrer-Costa, Puigmulé, Lopez, Pico, Arbelo, Jordà, Brugada, Brugada and Campuzano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Electrocardiogram
• dc.subject.keyword Family segregation
• dc.subject.keyword Genetics
• dc.subject.keyword Long QT syndrome
• dc.subject.keyword Sudden cardiac death
• dc.title Early identification of prolonged QT interval for prevention of sudden infant death
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion