Predictors of microbial agents in dust and respiratory health in the Ecrhs.

Tischer, Christina; Zock, Jan-Paul; Valkonen, Maria; Doekes, Gert; Guerra, Stefano; Heederik, Dick; Jarvis, Deborah; Norbäck, Dan; Olivieri, Mario; Sunyer Deu, Jordi; Svanes, Cecilie; Täubel, Martin; Thiering, Elisabeth; Verlato, Giuseppe; Hyvärinen, Anne; Heinrich, Joachim

Predictors of microbial agents in dust and respiratory health in the Ecrhs.

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dc.contributor.author Tischer, Christinaca
dc.contributor.author Zock, Jan-Paulca
dc.contributor.author Valkonen, Mariaca
dc.contributor.author Doekes, Gertca
dc.contributor.author Guerra, Stefanoca
dc.contributor.author Heederik, Dickca
dc.contributor.author Jarvis, Deborahca
dc.contributor.author Norbäck, Danca
dc.contributor.author Olivieri, Marioca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Svanes, Cecilieca
dc.contributor.author Täubel, Martinca
dc.contributor.author Thiering, Elisabethca
dc.contributor.author Verlato, Giuseppeca
dc.contributor.author Hyvärinen, Anneca
dc.contributor.author Heinrich, Joachimca
dc.date.accessioned 2015-06-03T06:56:58Z
dc.date.available 2015-06-03T06:56:58Z
dc.date.issued 2015
dc.description.abstract BACKGROUND: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. METHODS: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. RESULTS: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. CONCLUSION: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.ca
dc.description.sponsorship This work was supported by the European Commission as part of HITEA (Health Effects of Indoor Pollutants: Integrating microbial, toxicological and epidemiological approaches), Grant agreement no. 211488 under the Seventh Framework Programme. The (1,3)-ß-D-glucan analysis was funded by the Spanish Health Institute Carlos III, project FIS PS09/02668.
dc.format.mimetype application/pdfca
dc.identifier.citation Tischer C, Zock JP, Valkonen M, Doekes G, Guerra S, Heederik D. et al. Predictors of microbial agents in dust and respiratory health in the Ecrhs. BMC Pulm Med. 2015 May 2;15(1):48. DOI: 10.1186/s12890-015-0042-y.ca
dc.identifier.doi http://dx.doi.org/10.1186/s12890-015-0042-y
dc.identifier.issn 1471-2466
dc.identifier.uri http://hdl.handle.net/10230/23718
dc.language.iso engca
dc.publisher BioMed Centralca
dc.relation.ispartof BMC Pulmonary Medicine. 2015 May 2;15(1):48
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211488
dc.rights © 2015 Tischer et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Fongsca
dc.subject.other Asma -- Aspectes ambientalsca
dc.title Predictors of microbial agents in dust and respiratory health in the Ecrhs.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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