Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Goday Arno, Albertoca
• dc.contributor.author Farré Albaladejo, Magíca
• dc.contributor.author Rodríguez-Morató, Jose, 1987-ca
• dc.contributor.author Ramón Moros, José Manuelca
• dc.contributor.author Pérez Mañá, Claraca
• dc.contributor.author Papaseit Fontanet, Estherca
• dc.contributor.author Civit, Esterca
• dc.contributor.author Langohr, Klausca
• dc.contributor.author Carbó Banús, Marcel·líca
• dc.contributor.author Benaiges Foix, Davidca
• dc.contributor.author Castañer, Olgaca
• dc.contributor.author Flores-Le-Roux, Juana Antoniaca
• dc.contributor.author Pera Roman, Manuel Ramónca
• dc.contributor.author Grande Posa, Luísca
• dc.contributor.author Torre Fornell, Rafael de laca
• dc.date.accessioned 2018-07-09T08:10:18Z
• dc.date.issued 2017
• dc.description.abstract PURPOSE: The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). MATERIALS AND METHODS: In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy (n = 10) or Roux-en-Y gastric bypass (n = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study. RESULTS: Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery. CONCLUSIONS: Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).
• dc.format.mimetype application/pdf
• dc.identifier.citation Goday Arno A, Farré M, Rodríguez-Morató J, Ramon JM, Pérez-Mañá C, Papaseit E et al. Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism. Obesity Surgery. 2017 Dec;27(12):3194-201. DOI: 10.1007/s11695-017-2745-z
• dc.identifier.doi http://dx.doi.org/10.1007/s11695-017-2745-z
• dc.identifier.issn 0960-8923
• dc.identifier.uri http://hdl.handle.net/10230/35065
• dc.language.iso eng
• dc.publisher Springerca
• dc.relation.ispartof Obesity Surgery. 2017 Dec;27(12):3194-201
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s11695-017-2745-z
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Caffeine
• dc.subject.keyword Clinical trial
• dc.subject.keyword Gastric bypass
• dc.subject.keyword Metabolism
• dc.subject.keyword Morbid obesity
• dc.subject.keyword Paracetamol
• dc.subject.keyword Sleeve gastrectomy
• dc.subject.other Obesitat mòrbida -- Cirurgia
• dc.subject.other Cafeïna
• dc.subject.other Paracetamol
• dc.title Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolismca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion