Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study

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• dc.contributor.author Oliveras, Anna
• dc.contributor.author Armario, Pedro
• dc.contributor.author Sans Atxer, Laia
• dc.contributor.author Clará Velasco, Alberto
• dc.contributor.author Vázquez, Susana
• dc.contributor.author Molina Ferragut, Luis
• dc.contributor.author Pareja, Júlia
• dc.contributor.author Sierra, Alejandro de la
• dc.contributor.author Pascual Santos, Julio
• dc.date.accessioned 2018-11-26T08:28:17Z
• dc.date.issued 2018
• dc.description.abstract Renal denervation and spironolactone have both been proposed for the treatment of resistant hypertension, but their effects on preclinical target organ damage have not been compared. Twenty-four patients with 24-hour systolic blood pressure ≥140 mm Hg despite receiving three or more full-dose antihypertensive drugs, one a diuretic, were randomized to receive spironolactone or renal denervation. Changes in 24-hour blood pressure, urine albumin excretion, arterial stiffness, carotid intima-media thickness, and left ventricular mass index were evaluated at 6 months. Mean baseline-adjusted difference between the two groups (spironolactone vs renal denervation) at 6 months in 24-hour systolic blood pressure was -17.9 mm Hg (95% confidence interval [CI], -30.9 to -4.9; P = .01). Mean baseline-adjusted change in urine albumin excretion was -87.2 (95% CI, -164.5 to -9.9) and -23.8 (95% CI, -104.5 to 56.9), respectively (P = .028). Mean baseline-adjusted variation of 24-hour pulse pressure was -13.5 (95% CI, -18.8 to -8.2) and -2.1 (95% CI, -7.9 to 3.7), respectively (P = .006). The correlation of change in 24-hour systolic blood pressure with change in log-transformed urine albumin excretion was r = .713 (P < .001). At 6 months there was a reduction in albuminuria in patients with resistant hypertension treated with spironolactone as compared with renal denervation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Oliveras A, Armario P, Sans L, Clarà A, Vázquez S, Molina L. et al. Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study. J Clin Hypertens (Greenwich). 2018 Jan;20(1):69-75. DOI: 10.1111/jch.13156
• dc.identifier.doi http://dx.doi.org/10.1111/jch.13156
• dc.identifier.issn 1524-6175
• dc.identifier.uri http://hdl.handle.net/10230/35847
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof The Journal of Clinical Hypertension. 2018 Jan;20(1):69-75
• dc.rights This is the peer reviewed version of the following article: Oliveras A, Armario P, Sans L, Clarà A, Vázquez S, Molina L. et al. Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study. J Clin Hypertens (Greenwich). 2018 Jan;20(1):69-75, which has been published in final form at http://dx.doi.org/10.1111/jch.13156. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Albuminuria
• dc.subject.keyword Arterial stiffness
• dc.subject.keyword Carotid wall thickness
• dc.subject.keyword End organ damage
• dc.subject.keyword Left ventricular hypertrophy
• dc.subject.keyword Renal denervation
• dc.subject.keyword Spironolactone
• dc.subject.other Hipertensió
• dc.title Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The DENERVHTA (Denervación en Hipertensión Arterial) study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion