Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group

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• dc.contributor.author Eraso, Arantxa
• dc.contributor.author Sanz, Javier
• dc.contributor.author Mollà, Meritxell
• dc.contributor.author Reyes, Vicky
• dc.contributor.author Pedro, Agustí
• dc.contributor.author Arenas Prat, Meritxell
• dc.contributor.author Martínez, Evelyn
• dc.contributor.author Ballester, Rosa
• dc.contributor.author Cambra, Maria José
• dc.contributor.author García, Virginia
• dc.contributor.author Prades, Joan Lluis
• dc.contributor.author Borràs, Josep M.
• dc.contributor.author Algara López, Manuel-Ignacio
• dc.date.accessioned 2022-10-24T06:24:49Z
• dc.date.available 2022-10-24T06:24:49Z
• dc.date.issued 2022
• dc.description.abstract Introduction: Daily, moderate hypofractionation has become standard treatment for breast cancer following breast-conserving surgery, although substantial variation exists in its use. This paper describes the generation of consensus-based recommendations for the utilisation of this therapy at the healthcare system level and compares these to American Society for Radiation Oncology (ASTRO) guidelines. Materials and methods: Consensus-based guidelines were developed in three steps, including a systematic literature review and involvement of radiation oncologists specialising in breast cancer in Catalonia: (a) creation of a working group and evidence review; (b) consideration of the levels of evidence and agreement on the formulation of survey questions; and (c) performance of survey and development of consensus-based recommendations. Results were compared to the ASTRO recommendations. Results: Consensus was above 80% for 10 of the 14 survey items. Experts supported hypofractionated radiotherapy for all breast cancer patients aged 40 years or more; with invasive carcinoma and breast-conserving surgery; without radiation of lymph nodes; and regardless of the tumour size, histological grade, molecular subtype, breast size, laterality, other treatment characteristics, or need for a boost. Over half favoured its use in all situations, even where available scientific evidence is insufficient. The resulting recommendations and the quality of the evidence are comparable to those from ASTRO, despite some differences in the degree of consensus. Conclusion: Specialists agree that hypofractionation is the standard treatment for breast cancer following breast-conserving surgery, but some specific areas require a higher level of evidence before unequivocally extending indications.
• dc.format.mimetype application/pdf
• dc.identifier.citation Eraso A, Sanz J, Mollà M, Reyes V, Pedro A, Arenas M, Martinez E, Ballester R, Cambra MJ, García V, Prades JL, Borras JM, Algara M. Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group. Clin Transl Oncol. 2022 Aug;24(8):1580-7. DOI: 10.1007/s12094-022-02798-8
• dc.identifier.doi http://dx.doi.org/10.1007/s12094-022-02798-8
• dc.identifier.issn 1699-048X
• dc.identifier.uri http://hdl.handle.net/10230/54540
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Clin Transl Oncol. 2022 Aug;24(8):1580-7
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Breast cancer
• dc.subject.keyword Hypofractionation
• dc.subject.keyword Radiotherapy
• dc.title Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion