Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
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- dc.contributor.author Laurent, Olivier
- dc.contributor.author Cardis, Elisabeth
- dc.contributor.author Pernot, Eileen
- dc.contributor.author Turner, Michelle C.
- dc.contributor.author Laurier, Dominique
- dc.date.accessioned 2024-02-20T07:15:48Z
- dc.date.available 2024-02-20T07:15:48Z
- dc.date.issued 2016
- dc.description.abstract The potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium exposure. Experimental studies have shown that uranium has biological effects, but their implications for human health are not clear. New studies that would combine the strengths of large, well-designed epidemiological datasets with those of state-of-the-art biological methods would help improve the characterization of the biological and health effects of occupational uranium exposure. The aim of the European Commission concerted action CURE (Concerted Uranium Research in Europe) was to develop protocols for such a future collaborative research project, in which dosimetry, epidemiology and biology would be integrated to better characterize the effects of occupational uranium exposure. These protocols were developed from existing European cohorts of workers exposed to uranium together with expertise in epidemiology, biology and dosimetry of CURE partner institutions. The preparatory work of CURE should allow a large scale collaborative project to be launched, in order to better characterize the effects of uranium exposure and more generally of alpha particles and low doses of ionizing radiation.
- dc.description.sponsorship The CURE project was supported by the European Commission FP7 DoReMi Network of Excellence (grant number: 249689). MCT was funded by a Government of Canada Banting Postdoctoral Fellowship. PHE and Nuvia received partial funding from the UK Nuclear Decommissioning Authority. IRSN received partial funding from AREVA.
- dc.format.mimetype application/pdf
- dc.identifier.citation Laurent O, Gomolka M, Haylock R, Blanchardon E, Giussani A, Atkinson W, et al. Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure. J Radiol Prot. 2016 Jun;36(2):319-45. DOI: 10.1088/0952-4746/36/2/319
- dc.identifier.doi http://dx.doi.org/10.1088/0952-4746/36/2/319
- dc.identifier.issn 1361-6498
- dc.identifier.uri http://hdl.handle.net/10230/59151
- dc.language.iso eng
- dc.publisher IOP Publishing Ltd.
- dc.relation.ispartof Journal of Radiological Protection. 2016 Jun;36(2):319-45
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/249689
- dc.rights Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/3.0/
- dc.subject.keyword Uranium
- dc.subject.keyword Radionuclides
- dc.subject.keyword Dosimetry
- dc.subject.keyword Biomarkers
- dc.subject.keyword Molecular epidemiology
- dc.subject.keyword Epidemiology
- dc.subject.keyword Occupational exposure
- dc.title Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion