Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation

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  • dc.contributor.author Cantacorps Centellas, Lídia, 1991-
  • dc.contributor.author Alfonso-Loeches, Silvia
  • dc.contributor.author Guerri, Consuelo
  • dc.contributor.author Valverde Granados, Olga
  • dc.date.accessioned 2020-02-17T08:33:53Z
  • dc.date.available 2020-02-17T08:33:53Z
  • dc.date.issued 2019
  • dc.description.abstract Background: Alcohol exposure impairs brain development and leads to a range of behavioural and cognitive dysfunctions, termed as foetal alcohol spectrum disorders. Although different mechanisms have been proposed to participate in foetal alcohol spectrum disorders, the molecular insights of such effects are still uncertain. Using a mouse model of foetal alcohol spectrum disorder, we have previously shown that maternal binge-like alcohol drinking causes persistent effects on motor, cognitive and emotional-related behaviours associated with neuroimmune dysfunctions. Aims: In this study, we sought to evaluate whether the long-term behavioural alterations found in offspring with early exposure to alcohol are associated with epigenetic changes in the hippocampus and prefrontal cortex. Methods: Pregnant C57BL/6 female mice underwent a model procedure for binge alcohol drinking throughout both the gestation and lactation periods. Subsequently, adult offspring were assessed for their cognitive function in a reversal learning task and brain areas were extracted for epigenetic analyses. Results: The results demonstrated that early binge alcohol exposure induces long-term behavioural effects along with alterations in histone acetylation (histone H4 lysine 5 and histone H4 lysine 12) in the hippocampus and prefrontal cortex. The epigenetic effects were linked with an imbalance in histone acetyltransferase activity that was found to be increased in the prefrontal cortex of mice exposed to alcohol. Conclusions: In conclusion, our results reveal that maternal binge-like alcohol consumption induces persistent epigenetic modifications, effects that might be associated with the long-term cognitive and behavioural impairments observed in foetal alcohol spectrum disorder models.
  • dc.description.sponsorship The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by grants from the European Union’s Horizon 2020 research and innovation program 2014-2020 under Grant Agreement No 634143, Spanish Ministry of Economy, Innovation and Competitiveness (SAF2015-69187-R-FEDER; SAF2016-75347-R) and Spanish Ministry of Health (Retic-ISCIII-RD/12/0028/007 and RD/16/0017/0010-FEDER and Plan Nacional sobre Drogas #2014/020, #2015/010 and #2018/007). The Department of Experimental and Health Sciences (UPF) is a ‘Unidad de Excelencia María de Maeztu’ funded by the MINECO (ref. MDM-2014-0370).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Cantacorps L, Alfonso-Loeches S, Guerri C, Valverde O. Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation. J Psychopharmacol. 2019 Jun 18;33(12):1562-72. DOI 10.1177/0269881119856001
  • dc.identifier.doi http://dx.doi.org/10.1177/0269881119856001
  • dc.identifier.issn 0269-8811
  • dc.identifier.uri http://hdl.handle.net/10230/43608
  • dc.language.iso eng
  • dc.publisher SAGE Publications
  • dc.relation.ispartof Journal of Psychopharmacology. 2019 Jun 18;33(12):1562-72
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-69187-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75347-R
  • dc.rights Cantacorps L, Alfonso-Loeches S, Guerri C, Valverde O. Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation. J Psychopharmacol. 2019 Dec;33(12):1562-72. DOI: 10.1177/0269881119856001.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Alcohol binge drinking
  • dc.subject.keyword Cognition
  • dc.subject.keyword Epigenetics
  • dc.subject.keyword Foetal alcohol spectrum disorder
  • dc.subject.keyword Histone acetylation
  • dc.title Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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