1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research

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• dc.contributor.author Gallo, María, 1989-
• dc.contributor.author Defaus, Sira
• dc.contributor.author Andreu Martínez, David
• dc.date.accessioned 2025-10-28T17:38:35Z
• dc.date.available 2025-10-28T17:38:35Z
• dc.date.issued 2019
• dc.date.updated 2025-10-28T17:38:35Z
• dc.description.abstract In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell translocation properties, setting the ground for a new area of research that over the years has grown into considerable therapeutic potential. The vectors, named cell-penetrating peptides (CPPs), constitute a now large and diversified family, sharing the extraordinary ability to diffuse unaltered across cell membranes while ferrying diverse associated cargos. Such properties have made CPPs ideal tools for delivery of nucleic acids, proteins and other therapeutic/diagnostic molecules to cells and tissues via covalent conjugation or complexation. This year 2018 marks the 30th anniversary of a peptide research landmark opening new perspectives in drug delivery. Given its vastness, exhaustive coverage of the main features and accomplishments in the CPP field is virtually impossible. Hence this manuscript, after saluting the above 30th jubilee, focuses by necessity on the most recent contributions, providing a comprehensive list of recognized CPPs and their latest-reported applications over the last two years. In addition, it thoroughly reviews three areas of peptide vector research of particular interest to us, namely (i) efficient transport of low-bioavailability drugs into the brain; (ii) CPP-delivered disruptors of G protein-coupled receptor (GPCRs) heteromers related to several disorders, and (iii) CPP-mediated delivery of useful but poorly internalized drugs into parasites.
• dc.description.sponsorship Work supported by the Spanish Ministry of Economy and Competitiveness (MINECO), grants SAF2011-24899 and AGL2014-52395-C2 (to D.A.) and “María de Maeztu” Program for Units of Excellence in R&D (to Pompeu Fabra University). Additional support from the EU Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) grant 644167, 2015–2019 (D.A. & S.D.).
• dc.format.mimetype application/pdf
• dc.identifier.citation Gallo M, Defaus S, Andreu D. 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research. Arch Biochem Biophys. 2019 Jan:661:74-86. DOI: 10.1016/j.abb.2018.11.010
• dc.identifier.doi http://dx.doi.org/10.1016/j.abb.2018.11.010
• dc.identifier.issn 0003-9861
• dc.identifier.uri http://hdl.handle.net/10230/71681
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Archives of Biochemistry and Biophysics. 2019;661:74-86
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-24899
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/644167
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.abb.2018.11.010
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cell-penetrating peptides
• dc.subject.keyword Drug delivery
• dc.subject.keyword Blood-brain barrier
• dc.subject.keyword Trans-membrane helix cross-talk disruptor peptides
• dc.subject.keyword Anti-parasitic drugs
• dc.title 1988-2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion