Chromosomal bands affected by acute oil exposure and DNA repair errors
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- dc.contributor.author Monyarch, Gemmaca
- dc.contributor.author De Castro Reis, Fernandaca
- dc.contributor.author Zock, Jan-Paulca
- dc.contributor.author Giraldo, Jesúsca
- dc.contributor.author Pozo Rodríguez, Franciscoca
- dc.contributor.author Espinosa Díaz, Anaca
- dc.contributor.author Rodríguez Trigo, Gemaca
- dc.contributor.author Gómez, Federico P.ca
- dc.contributor.author Antó i Boqué, Josep Mariaca
- dc.contributor.author Coll, Mariaca
- dc.contributor.author Barberà, Joan Albertca
- dc.contributor.author Fuster, Carmeca
- dc.date.accessioned 2015-05-15T07:10:33Z
- dc.date.available 2015-05-15T07:10:33Z
- dc.date.issued 2013ca
- dc.description.abstract Background: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk. Objectives: We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency. Methods: Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin. Results: Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0.016). Conclusion: The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.en
- dc.description.sponsorship For this study was provided by grants from the Health Institute Carlos III FEDER/ERDF (PI03/1685), Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Comissionat per a Universitats i Recerca from Generalitat de Catalunya (SGR09-1107), Centro de Investigación en Red de Enfermedades Respiratorias and Universidad Autónoma de Barcelona (PS-456-01/08).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Monyarch G, De Castro Reis F, Zock JP, Giraldo J, Pozo-Rodriguez F, Espinosa A et al. Chromosomal bands affected by acute oil exposure and DNA repair errors. PLoS ONE. 2013;8(11):e81276. DOI: 10.1371/journal.pone.0081276ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0081276
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23587
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2013;8(11):e81276
- dc.rights © 2013 Fuster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/3.0/
- dc.subject.other Limfòcitsca
- dc.subject.other ADN -- Reparacióca
- dc.title Chromosomal bands affected by acute oil exposure and DNA repair errorsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca