The dental proteome of Homo antecessor

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• dc.contributor.author Welker, Frido
• dc.contributor.author Chiva, Cristina
• dc.contributor.author Kuhlwilm, Martin
• dc.contributor.author Manuel Montero, Marc de, 1991-
• dc.contributor.author Gelabert Xirinachs, Pere, 1991-
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.contributor.author Sabidó Aguadé, Eduard, 1981-
• dc.contributor.author Lalueza Fox, Carles, 1965-
• dc.contributor.author Cappellini, Enrico
• dc.date.accessioned 2022-01-27T07:48:14Z
• dc.date.available 2022-01-27T07:48:14Z
• dc.date.issued 2020
• dc.description.abstract The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo sapiens, are highly debated1-5. For the oldest remains, the molecular study of these relationships is hindered by the degradation of ancient DNA. However, recent research has demonstrated that the analysis of ancient proteins can address this challenge6-8. Here we present the dental enamel proteomes of H. antecessor from Atapuerca (Spain)9,10 and Homo erectus from Dmanisi (Georgia)1, two key fossil assemblages that have a central role in models of Pleistocene hominin morphology, dispersal and divergence. We provide evidence that H. antecessor is a close sister lineage to subsequent Middle and Late Pleistocene hominins, including modern humans, Neanderthals and Denisovans. This placement implies that the modern-like face of H. antecessor-that is, similar to that of modern humans-may have a considerably deep ancestry in the genus Homo, and that the cranial morphology of Neanderthals represents a derived form. By recovering AMELY-specific peptide sequences, we also conclude that the H. antecessor molar fragment from Atapuerca that we analysed belonged to a male individual. Finally, these H. antecessor and H. erectus fossils preserve evidence of enamel proteome phosphorylation and proteolytic digestion that occurred in vivo during tooth formation. Our results provide important insights into the evolutionary relationships between H. antecessor and other hominin groups, and pave the way for future studies using enamel proteomes to investigate hominin biology across the existence of the genus Homo.
• dc.description.sponsorship F.W. is supported by a Marie Skłodowska Curie Individual Fellowship (no. 795569). E. Cappellini was supported by VILLUM FONDEN (no. 17649). E.W. is supported by the Lundbeck Foundation, the Danish National Research Foundation, the Novo Nordisk Foundation, the Carlsberg Foundation, KU2016 and the Wellcome Trust. Without the effort of the members of the Atapuerca research team during fieldwork, this work would have not been possible; we make a special mention of J. Rosell, who supervises the excavation of the TD6 level. The research of the Atapuerca project has been supported by the Dirección General de Investigación of the Ministerio de Ciencia, Innovación y Universidades (grant numbers PGC2018-093925-B-C31, C32, and C33); field seasons are supported by the Consejería de Cultura y Turismo of the Junta de Castilla y León and the Fundación Atapuerca. We acknowledge The Leakey Foundation through the personal support of G. Getty (2013) and D. Crook (2014–2016, 2018, and 2019) to M.M.-T., as well as F.W. (2017). Restoration and conservation work on the material have been carried out by P. Fernández-Colón and E. Lacasa from the Conservation and Restoration Area of CENIEH-ICTS and L. López-Polín from IPHES. The picture of the specimen ATD6-92 was made by M. Modesto-Mata. E. Cappellini, J.C., J.V.O. and P. Gutenbrunner are supported by the Marie Skłodowska-Curie European Training Network (ETN) TEMPERA, a project funded by the European Union’s Framework Program for Research and Innovation Horizon 2020 (grant agreement no. 722606). Amino acid analyses were undertaken thanks to the Leverhulme Trust (PLP-2012-116) and NERC (NE/K500987/1). T.M.-B. is supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, Obra Social ‘La Caixa’ and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880). C.L.-F. is supported by a FEDER-MINECO grant (PGC2018-095931-B-100). M.K. was supported by the Postdoctoral Junior Leader Fellowship Programme from ‘la Caixa’ Banking Foundation (LCF/BQ/PR19/11700002). M.M. is supported by the Danish National Research Foundation award PROTEIOS (DNRF128). Work at the Novo Nordisk Foundation Center for Protein Research is funded in part by a donation from the Novo Nordisk Foundation (grant number NNF14CC0001).
• dc.format.mimetype application/pdf
• dc.identifier.citation Welker F, Ramos-Madrigal J, Gutenbrunner P, Mackie M, Tiwary S, Rakownikow Jersie-Christensen R et al. The dental proteome of Homo antecessor. Nature. 2020;580(7802):235-8. DOI: 10.1038/s41586-020-2153-8
• dc.identifier.doi http://dx.doi.org/10.1038/s41586-020-2153-8
• dc.identifier.issn 0028-0836
• dc.identifier.uri http://hdl.handle.net/10230/52337
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature. 2020;580(7802):235-8
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/722606
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-093925-B-C31
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-093925-B-C32
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-093925-B-C33
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-095931-B-100
• dc.rights © Springer Nature Publishing AG Welker F, Ramos-Madrigal J, Gutenbrunner P, Mackie M, Tiwary S, Rakownikow Jersie-Christensen R et al. The dental proteome of Homo antecessor. Nature. 2020; 580(7802):235-8. DOI: 10.1038/s41586-020-2153-8 [http://dx.doi.org/10.1038/s41586-020-2153-8]
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Biological anthropology
• dc.subject.keyword Evolutionary biology
• dc.subject.keyword Evolutionary genetics
• dc.subject.keyword Proteomic analysis
• dc.title The dental proteome of Homo antecessor
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion