Red blood cell DHA is inversely associated with risk of incident alzheimer's disease and all-cause dementia: framingham offspring study

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• dc.contributor.author Sala Vila, Aleix
• dc.contributor.author Satizabal, Claudia L.
• dc.contributor.author Tintle, Nathan
• dc.contributor.author Melo van Lent, Debora
• dc.contributor.author Vasan, Ramachandran S.
• dc.contributor.author Beiser, Alexa S.
• dc.contributor.author Seshadri, Sudha
• dc.contributor.author Harris, William S.
• dc.date.accessioned 2022-11-29T07:41:18Z
• dc.date.available 2022-11-29T07:41:18Z
• dc.date.issued 2022
• dc.description.abstract Docosahexaenoic acid (DHA) might help prevent Alzheimer's disease (AD). Red blood cell (RBC) status of DHA is an objective measure of long-term dietary DHA intake. In this prospective observational study conducted within the Framingham Offspring Cohort (1490 dementia-free participants aged ≥65 years old), we examined the association of RBC DHA with incident AD, testing for an interaction with APOE-ε4 carriership. During the follow-up (median, 7.2 years), 131 cases of AD were documented. In fully adjusted models, risk for incident AD in the highest RBC DHA quintile (Q5) was 49% lower compared with the lowest quintile (Q1) (Hazard ratio [HR]: 0.51, 95% confidence interval [CI]: 0.27, 0.96). An increase in RBC DHA from Q1 to Q5 was predicted to provide an estimated 4.7 additional years of life free of AD. We observed an interaction DHA × APOE-ε4 carriership for AD. Borderline statistical significance for a lower risk of AD was observed per standard deviation increase in RBC DHA (HR: 0.71, 95% CI: 0.51, 1.00, p = 0.053) in APOE-ε4 carriers, but not in non-carriers (HR: 0.85, 95% CI: 0.65, 1.11, p = 0.240). These findings add to the increasing body of literature suggesting a robust association worth exploring dietary DHA as one strategy to prevent or delay AD.
• dc.format.mimetype application/pdf
• dc.identifier.citation Sala-Vila A, Satizabal CL, Tintle N, Melo van Lent D, Vasan RS, Beiser AS, et al. Red blood cell DHA is inversely associated with risk of incident alzheimer's disease and all-cause dementia: framingham offspring study. Nutrients. 2022 Jun 9; 14(12): 2408. DOI: 10.3390/nu14122408
• dc.identifier.doi http://dx.doi.org/10.3390/nu14122408
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/55028
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2022, by Sala-Vila A, Satizabal CL, Tintle N, Melo van Lent D, Vasan RS, Beiser AS, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Brain health
• dc.subject.keyword Elders
• dc.subject.keyword Lipids
• dc.subject.keyword Neurodegeneration
• dc.subject.keyword Omega-3
• dc.title Red blood cell DHA is inversely associated with risk of incident alzheimer's disease and all-cause dementia: framingham offspring study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion