Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients

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• dc.contributor.author Mercader Bigas, Josep Mariaca
• dc.contributor.author Fernández Aranda, Fernandoca
• dc.contributor.author Gratacós Mayora, Mònicaca
• dc.contributor.author Ribasés, Martaca
• dc.contributor.author Badía, Annaca
• dc.contributor.author Villarejo, Cynthiaca
• dc.contributor.author Solano, Raquelca
• dc.contributor.author González Ruiz, Juan Ramónca
• dc.contributor.author Vallejo, Julioca
• dc.contributor.author Estivill, Xavier, 1955-ca
• dc.date.accessioned 2012-05-31T10:32:55Z
• dc.date.available 2012-05-31T10:32:55Z
• dc.date.issued 2007ca
• dc.description.abstract Background: Evidence of a role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of eating disorders (ED) has been provided by association studies and by murine models. BDNF plasma levels have been found altered in ED and in psychiatric disorders that show comorbidity with ED. Aims: Since the role of BDNF levels in ED-related psychopathological symptoms has not been tested, we investigated/nthe correlation of BDNF plasma levels with the Symptom Checklist 90 Revised (SCL-90R) questionnaire in a total of 78 ED patients. Methods: BDNF levels, measured by/nthe enzyme-linked immunoassay system, and SCL-90R questionnaire, were assessed in a total of 78 ED patients. The relationship between BDNF levels and SCL-90R scales was calculated using a general linear model. Results: BDNF plasma levels correlated with the Global Severity Index and the Positive Symptom Distress Index global scales and five of the nine subscales in the anorexia nervosa patients. BDNF plasma levels were able to explain, in the case of the Psychoticism subscale, up to 17% of the variability (p = 0.006). Conclusion: Our data suggest that BDNF levels could be involved in the severity of the disease through the modulation of psychopathological traits that are associated with the ED phenotype.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Mercader JM, Fernández-Aranda F, Gratacòs M, Ribasés M, Badía A, Villarejo C et al. Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients. Neuropsychobiology. 2007;56(4):185-90. DOI: 10.1159/000120623ca
• dc.identifier.doi http://dx.doi.org/10.1159/000120623
• dc.identifier.issn 0302-282Xca
• dc.identifier.uri http://hdl.handle.net/10230/16494
• dc.language.iso engca
• dc.publisher Karger (S. Karger AG)ca
• dc.relation.ispartof Neuropsychobiology. 2007;56(4):185-90
• dc.rights © 2007 S. Karger AG, Baselca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Brain-derived neurotrophic factor
• dc.subject.keyword Eating disorders
• dc.subject.keyword Anorexia nervosa
• dc.subject.keyword Bulimia nervosa
• dc.subject.keyword Psychopathology
• dc.subject.keyword Anxiety
• dc.subject.keyword Depression
• dc.subject.keyword Obsessive-compulsiveness
• dc.subject.other Trastorns de la conducta alimentària -- Aspectes genètics
• dc.subject.other Anorèxia nerviosa
• dc.subject.other Bulímia
• dc.title Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patientsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/submittedVersion