Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. A randomized, double-blind, placebo-controlled functional magnetic resonance imaging study

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• dc.contributor.author Monfort Faure, Jorgeca
• dc.contributor.author Pujol Nuez, Jesúsca
• dc.contributor.author Contreras-Rodríguez, O.ca
• dc.contributor.author Llorente-Onaindia, J.ca
• dc.contributor.author López-Solà, Marinaca
• dc.contributor.author Blanco Hinojo, Laura, 1981-ca
• dc.contributor.author Vergés, Josepca
• dc.contributor.author Herrero, Martaca
• dc.contributor.author Sánchez, Lauraca
• dc.contributor.author Ortiz, Héctorca
• dc.contributor.author Montañés, F.ca
• dc.contributor.author Deus, Joanca
• dc.contributor.author Benito Ruiz, Pedroca
• dc.date.accessioned 2018-01-29T08:49:31Z
• dc.date.issued 2017
• dc.description.abstract INTRODUCTION: Knee osteoarthritis is causing pain and functional disability. One of the inherent problems with efficacy assessment of pain medication was the lack of objective pain measurements, but functional magnetic resonance imaging (fMRI) has emerged as a useful means to objectify brain response to painful stimulation. We have investigated the effect of chondroitin sulfate (CS) on brain response to knee painful stimulation in patients with knee osteoarthritis using fMRI. METHODS: Twenty-two patients received CS (800mg/day) and 27 patients placebo, and were assessed at baseline and after 4 months of treatment. Two fMRI tests were conducted in each session by applying painful pressure on the knee interline and on the patella surface. The outcome measurement was attenuation of the response evoked by knee painful stimulation in the brain. RESULTS: fMRI of patella pain showed significantly greater activation reduction under CS compared with placebo in the region of the mesencephalic periaquecductal gray. The CS group, additionally showed pre/post-treatment activation reduction in the cortical representation of the leg. No effects of CS were detected using the interline pressure test. CONCLUSIONS: fMRI was sensitive to objectify CS effects on brain response to painful pressure on patellofemoral cartilage, which is consistent with the known CS action on chondrocyte regeneration. The current work yields further support to the utility of fMRI to objectify treatment effects on osteoarthritis pain.
• dc.description.sponsorship This work was supported in part by the Ministry of Science and Innovation of Spain (Grant SAF2010-19434) and by Bioiberica, SA, Barcelona. M. López-Solà and J. Deus are part of the Research Group SGR 1450 from the Agency of University and Research Funding Management of the Catalan Government and M. López-Solà is supported by the post-doctoral fellowship Beatriu de Pinós awarded by the Agency for the Management of University and Research funding (Agència de Gestió d’Ajuts Universitaris i de Recerca; AGAUR), from the Catalan Government (2010 BP_A 00136).
• dc.format.mimetype application/pdf
• dc.identifier.citation Monfort J, Pujol J, Contreras-Rodríguez O, Llorente-Onaindia J, López-Solà M, Blanco-Hinojo L. et al. Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. A randomized, double-blind, placebo-controlled functional magnetic resonance imaging study. Med Clin (Barc). 2017 Jun 21;148(12):539-547. DOI: 10.1016/j.medcli.2016.12.036
• dc.identifier.doi http://dx.doi.org/10.1016/j.medcli.2016.12.036
• dc.identifier.issn 0025-7753
• dc.identifier.uri http://hdl.handle.net/10230/33772
• dc.language.iso eng
• dc.publisher Elsevierca
• dc.relation.ispartof Medicina Clinica. 2017 Jun 21;148(12):539-47
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-19434
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.medcli.2016.12.036
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Artrosis de rodilla
• dc.subject.keyword Chondroitin sulfate
• dc.subject.keyword Condroitín sulfato
• dc.subject.keyword Dolor
• dc.subject.keyword Functional magnetic resonance image
• dc.subject.keyword Knee osteoarthritis
• dc.subject.keyword Pain
• dc.subject.keyword Resonancia magnética funcional
• dc.subject.other Genolls -- Malalties
• dc.subject.other Artritis
• dc.title Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. A randomized, double-blind, placebo-controlled functional magnetic resonance imaging studyca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion