Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up
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- dc.contributor.author Fernandez, Mariana F.ca
- dc.contributor.author Pumarega Rodríguez, José Antonioca
- dc.contributor.author Porta Serra, Miquelca
- dc.contributor.author Molina-Molina, Jose Manuelca
- dc.contributor.author Arrebola, Juan Pedroca
- dc.contributor.author Olea, Nicolásca
- dc.date.accessioned 2018-03-02T08:57:03Z
- dc.date.issued 2017
- dc.description.abstract We aimed to assess changes in the total effective xenoestrogen burden (TEXB) -a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women. TEXB values significantly increased over follow-up (p <0.001); the largest difference was observed at 6-12 months post-surgery (p <0.001); then decreased over time. TEXB-alpha at 6-18 months was significantly higher in younger patients with estrogen receptor positivity (p=0.034) and in those receiving anti-neoplasm chemotherapy. Cancer treatment may be responsible for the increase in TEXB-alpha observed in patients with hormone-dependent tumors, which may confer to xenoestrogens a role in the progression of the disease.
- dc.format.mimetype application/pdf
- dc.identifier.citation Fernandez MF, Pumarega J, Porta M, Molina-Molina JM, Arrebola JP, Olea N. Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up. Reprod Toxicol. 2017 Apr;69:212-220. DOI: 10.1016/j.reprotox.2017.03.007
- dc.identifier.doi http://dx.doi.org/10.1016/j.reprotox.2017.03.007
- dc.identifier.issn 0890-6238
- dc.identifier.uri http://hdl.handle.net/10230/34032
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Reproductive Toxicology. 2017 Apr;69:212-20
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.reprotox.2017.03.007
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword TEXB
- dc.subject.keyword Breast cancer
- dc.subject.keyword Cancer treatment
- dc.subject.keyword Chemotherapy
- dc.subject.keyword Estrogen receptor tumors
- dc.subject.keyword Follow up
- dc.subject.keyword Total effective xenoestrogen burden
- dc.subject.other Càncer -- Tractament
- dc.subject.other Quimioteràpia
- dc.title Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-upca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion