A role for CD154, the CD40 ligand, in granulomatous inflammation

Villeneuve, Julien; Desmoulière, Alexis; Dewitte, Antoine; Bordeau, Nelly; Costet, Pierre; Bassaganyas Bars, Laia, 1985-; Fricain, Jean Christophe; Ripoche, Jean; Lepreux, Sébastien

doi:http://dx.doi.org/10.1155/2017/2982879

A role for CD154, the CD40 ligand, in granulomatous inflammation

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Villeneuve J, Desmoulière A, Dewitte A, Bordeau N, Costet P, Bassaganyas L et al. A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation. Mediators Inflamm. 2017;2017:2982879. DOI: 10.1155/2017/2982879. Epub 2017 Jul 12

Abstract

Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.